Advances in single-cell RNA sequencing (scRNA-seq) have allowed for comprehensive
analysis of the immune system. In this Review, we briefly describe the available scRNA-seq …

BACKGROUND The birth, death, and diversification of individuals are events that drive
biological processes across all scales. This is true whether the individuals in question …

Hematopoietic stem/progenitor cells (HSPCs) are capable of supporting the lifelong
production of blood cells exerting a wide spectrum of functions. Lentiviral vector HSPC gene …

Organismal ageing results from interlinked molecular changes in multiple organs over time.
The study of ageing at the molecular level is complicated by varying decay characteristics …

More than 20 years ago, X-linked severe combined immunodeficiency (SCID-X1) appeared
to be the best condition to test the feasibility of hematopoietic stem cell gene therapy. The …

T cells are continually generated in the thymus in a highly dynamic process comprising
discrete steps of lineage commitment, T cell receptor (TCR) gene rearrangement, and …

Leukaemia progressively invades bone marrow (BM), outcompeting healthy haematopoiesis
by mechanisms that are not fully understood. Combining cell number measurements with a …

The adaptive immune system is a dynamical, self-organized multiscale system that protects
vertebrates from both pathogens and internal irregularities, such as tumors. For these …

An innovative theory proposes a new therapeutic strategy to break the stalemate in the war
on cancer. It is called cancer stem cell (CSC) theory, and Lucie Laplane offers a …

Hematopoietic stem cells (HSCs) and downstream progenitors have long been studied
based on phenotype, cell purification, proliferation, and transplantation into myeloablated …