Animal models of atrial fibrillation

D Schüttler, A Bapat, S Kääb, K Lee, P Tomsits… - Circulation …, 2020 - Am Heart Assoc
Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in humans and
is a significant source of morbidity and mortality. Despite its prevalence, our mechanistic …

Are interactions between epicardial adipose tissue, cardiac fibroblasts and cardiac myocytes instrumental in atrial fibrosis and atrial fibrillation?

A Krishnan, E Chilton, J Raman, P Saxena… - Cells, 2021 - mdpi.com
Atrial fibrillation is very common among the elderly and/or obese. While myocardial fibrosis
is associated with atrial fibrillation, the exact mechanisms within atrial myocytes and …

Histological evaluation of cardiac remodelling in equine athletes

LC Nath, A Saljic, R Buhl, A Elliott, A La Gerche… - Scientific Reports, 2024 - nature.com
Abstract Approximately 1–2 per 100,000 young athletes die from sudden cardiac death
(SCD) and extreme exercise may be associated with myocardial scar and arrhythmias …

Vericiguat reduces electrical and structural remodeling in a rabbit model of atrial fibrillation

Q Lou, L Li, G Liu, T Li, L Zhang… - Journal of …, 2023 - journals.sagepub.com
Purpose: The molecular etiology of atrial fibrillation (AF) and its treatment are poorly
understood. AF involves both electrical and structural features. Vericiguat can ameliorate …

Atrial fibrosis and substrate based characterization in atrial fibrillation: time to move forwards

JX Quah, D Dharmaprani, K Tiver… - Journal of …, 2021 - Wiley Online Library
Atrial fibrillation (AF) is the most commonly encountered cardiac arrhythmia in clinical
practice. However, current therapeutic interventions for atrial fibrillation have limited clinical …

Atrial fibrillation in horses part 1: Pathophysiology

A Decloedt, G Van Steenkiste, L Vera, R Buhl… - The Veterinary …, 2020 - Elsevier
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia in horses, with a
reported prevalence up to 2.5%. The pathophysiology has mainly been investigated in …

Electrocardiographic characteristics of trained and untrained standardbred racehorses

SD Nissen, R Weis, EK Krag‐Andersen… - Journal of veterinary …, 2022 - Wiley Online Library
Background Long‐term exercise induces cardiac remodeling that potentially influences the
electrical properties of the heart. Hypothesis/objectives We assessed whether training alters …

Heart failure, female sex, and atrial fibrillation are the main drivers of human atrial cardiomyopathy: results from the CATCH ME consortium

J Winters, A Isaacs, S Zeemering… - Journal of the …, 2023 - Am Heart Assoc
Background Atrial cardiomyopathy (atCM) is an emerging prognostic factor in cardiovascular
disease. Fibrotic remodeling, cardiomyocyte hypertrophy, and capillary density are …

Effect of selective IK,ACh inhibition by XAF‐1407 in an equine model of tachypacing‐induced persistent atrial fibrillation

MF Fenner, H Carstensen… - British journal of …, 2020 - Wiley Online Library
Background and Purpose Inhibition of the G‐protein gated ACh‐activated inward rectifier
potassium current, IK, ACh may be an effective atrial selective treatment strategy for atrial …

JavaCyte, a novel open-source tool for automated quantification of key hallmarks of cardiac structural remodeling

J Winters, ME Von Braunmuhl, S Zeemering… - Scientific reports, 2020 - nature.com
Many cardiac pathologies involve changes in tissue structure. Conventional analysis of
structural features is extremely time-consuming and subject to observer bias. The possibility …