Interactions between food and drugs may inadvertently reduce or increase the drug effect.
The majority of clinically relevant food-drug interactions are caused by food-induced …

Food-drug interactions can be associated with alterations in the pharmacokinetic and
pharmacodynamic profile of various drugs that may have clinical implications. The various …

Since 1975, Robert Julien's A Primer of Drug Action has been the definitive guide to the
effects of psychoactive drugs on the brain and on behavior. Now fully updated, this popular …

The elderly consume a disproportionate amount of prescription and nonprescription
medications. Alterations in physiology, polypharmacy, multiple prescribers, and other factors …

Introduction: Since their initial discovery in 1989, grapefruit juice (GFJ)–drug interactions
have received extensive interest from the scientific, medical, regulatory and lay communities …

More than a decade has passed since it was unintentionally discovered that grapefruit juice
interacts with certain drugs. The coadministration of these drugs with grapefruit juice can …

Background: Carbamazepine has been used as AEDs since 1965, and is most effective
against partial seizures. Two basic mechanisms of action have been proposed: 1) …

Grapefruit juice, a beverage consumed in large quantities by the general population, is an
inhibitor of the intestinal cytochrome P-450 3A4 system, which is responsible for the first …

It has been established that the absorption of many drugs from the small intestine is
hindered by the detoxification systems which are present in this epithelial tissue. In this …

We evaluated the effects of 25 purified components of commonly used herbal products on
the catalytic activity of cDNA-expressed cytochrome P450 isoforms in in vitro experiments …