Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …

Plasmodium vivax is a major cause of febrile illness in endemic areas of Asia, Central and
South America, and the horn of Africa. Plasmodium vivax infections are characterized by …

Malaria remains a major cause of morbidity and mortality in the tropics, with Plasmodium
falciparum responsible for the majority of the disease burden and P. vivax being the …

Artemisinins are the most rapidly acting of currently available antimalarial drugs. Artesunate
has become the treatment of choice for severe malaria, and artemisinin-based combination …

Primaquine is the only generally available anti-malarial that prevents relapse in vivax and
ovale malaria, and the only potent gametocytocide in falciparum malaria. Primaquine …

Clinical studies and mathematical models predict that, to achieve malaria elimination,
combination therapies will need to incorporate drugs that block the transmission of …

Background Late treatment failures after artemisinin-based combination therapies (ACTs) for
falciparum malaria have increased in the Greater Mekong subregion in southeast Asia …

Background Plasmodium falciparum resistance to artemisinins, the first line treatment for
malaria worldwide, has been reported in western Cambodia. Resistance is characterized by …

The deployment of artesunate for severe malaria and the artemisinin combination therapies
(ACTs) for uncomplicated malaria has been a major advance in antimalarial therapeutics …

Background An acute episode of malaria can be followed by multiple recurrent episodes
either due to re-infection, recrudescence of a partially treated parasite or, in the case of …