Abstract Titanium (Ti) and Ti alloys are commonly used in dental implants, which have good
biocompatibility, mechanical strength, processability, and corrosion resistance. However, the …

Neuropathic pain resulting from damage or dysfunction of the nervous system is a highly
debilitating chronic pain state and is often resistant to currently available treatments. It has …

Chronic pain resulting from nerve injury, tissue inflammation, and tumor invasion or
treatment, is a major health problem impacting the quality of life and producing a significant …

Interleukin-6 is an inflammatory cytokine with wide-ranging biological effects. It has been
widely demonstrated that neuroinflammation plays a critical role in the development of …

Cancer is a devastating disease that has plagued humans from ancient times to this day.
After decades of slow research progress, promising drug development, and the identification …

Magnesium has been investigated as a biodegradable metallic material. Increased
concentrations of Mg 2+ around magnesium implants due to biodegradation contribute to its …

Chronic pain is among the most disabling and costly disorders, with prevalence ranging
from 10% to 55%. However, current therapeutic strategies for chronic pain are unsatisfactory …

Chemokines and receptors have been implicated in the pathogenesis of chronic pain. Here,
we report that spinal nerve ligation (SNL) increased CXCR3 expression in dorsal root …

Aim: To investigate the mechanisms underlying the anti-nociceptive effect of minocycline on
bone cancer pain (BCP) in rats. Methods: A rat model of BCP was established by inoculating …

Chronic pain remains to be a clinical challenge due to insufficient therapeutic strategies.
Minocycline is a member of the tetracycline class of antibiotics, which has been used in …