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A journey from structure to function of bacterial lipopolysaccharides
Lipopolysaccharide (LPS) is a crucial constituent of the outer membrane of most Gram-
negative bacteria, playing a fundamental role in the protection of bacteria from …
negative bacteria, playing a fundamental role in the protection of bacteria from …
[HTML][HTML] Mammalian transient receptor potential TRPA1 channels: from structure to disease
The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …
cation channels remarkably conserved through the animal kingdom. Mammals have only …
Sensory neurons, neuroimmunity, and pain modulation by sex hormones
The inclusion of women in preclinical pain studies has become more commonplace in the
last decade as the National Institutes of Health (NIH) released its “Sex as a Biological …
last decade as the National Institutes of Health (NIH) released its “Sex as a Biological …
[HTML][HTML] TRPA1 expression and pathophysiology in immune cells
The non-selective cation channel TRPA1 is best known as a broadly-tuned sensor
expressed in nociceptive neurons, where it plays key functions in chemo-, thermo-, and …
expressed in nociceptive neurons, where it plays key functions in chemo-, thermo-, and …
Liquiritin, a novel inhibitor of TRPV1 and TRPA1, protects against LPS-induced acute lung injury
Z Liu, P Wang, S Lu, R Guo, W Gao, H Tong, Y Yin… - Cell calcium, 2020 - Elsevier
TRPV1 and TRPA1 are cation channels that play key roles in inflammatory signaling
pathways. They are co-expressed on airway C-fibers, where they exert synergistic effects on …
pathways. They are co-expressed on airway C-fibers, where they exert synergistic effects on …
[HTML][HTML] The role of transient receptor potential (TRP) channels in the transduction of dental pain
Dental pain is a common health problem that negatively impacts the activities of daily living.
Dentine hypersensitivity and pulpitis-associated pain are among the most common types of …
Dentine hypersensitivity and pulpitis-associated pain are among the most common types of …
[HTML][HTML] TRPV protein family—from mechanosensing to cancer invasion
Biophysical cues from the cellular microenvironment are detected by mechanosensitive
machineries that translate physical signals into biochemical signaling cascades. At the …
machineries that translate physical signals into biochemical signaling cascades. At the …
TRP channels in health and disease at a glance
The transient receptor potential (TRP) channel superfamily consists of a large group of non-
selective cation channels that serve as cellular sensors for a wide spectrum of physical and …
selective cation channels that serve as cellular sensors for a wide spectrum of physical and …
Adipose-derived exosomes protect the pulmonary endothelial barrier in ventilator-induced lung injury by inhibiting the TRPV4/Ca2+ signaling pathway
Q Yu, D Wang, X Wen, X Tang, D Qi… - … of Physiology-Lung …, 2020 - journals.physiology.org
Mechanical ventilation (MV) is the main supportive treatment of acute respiratory distress
syndrome (ARDS), but it may lead to ventilator-induced lung injury (VILI). Large …
syndrome (ARDS), but it may lead to ventilator-induced lung injury (VILI). Large …
TRP channels as sensors of chemically-induced changes in cell membrane mechanical properties
Transient Receptor Potential ion channels (TRPs) have been described as polymodal
sensors, being responsible for transducing a wide variety of stimuli, and being involved in …
sensors, being responsible for transducing a wide variety of stimuli, and being involved in …