Involvement of astrocytes in the formation, maintenance, and function of the blood–brain barrier

G Schiera, CM Di Liegro, G Schirò, G Sorbello… - Cells, 2024 - mdpi.com
The blood–brain barrier (BBB) is a fundamental structure that protects the composition of the
brain by determining which ions, metabolites, and nutrients are allowed to enter the brain …

Looking at the blood–brain barrier: molecular anatomy and possible investigation approaches

FL Cardoso, D Brites, MA Brito - Brain research reviews, 2010 - Elsevier
The blood–brain barrier (BBB) is a dynamic and complex interface between blood and the
central nervous system that strictly controls the exchanges between the blood and brain …

A 3D neurovascular microfluidic model consisting of neurons, astrocytes and cerebral endothelial cells as a blood–brain barrier

G Adriani, D Ma, A Pavesi, RD Kamm, ELK Goh - Lab on a Chip, 2017 - pubs.rsc.org
The neurovascular unit is a complex, interdependent system composed of neurons and
neural supporting cells, such as astrocytes, as well as cells that comprise the vascular …

From adsorption to covalent bonding: Apolipoprotein E functionalization of polymeric nanoparticles for drug delivery across the blood–brain barrier

N Hartl, F Adams, OM Merkel - Advanced therapeutics, 2021 - Wiley Online Library
The blood–brain barrier (BBB) is composed of brain endothelial cells, pericytes, and
astrocytes, which build a tight cellular barrier. Therapeutic (macro) molecules are not able to …

Permeability studies on in vitro blood–brain barrier models: physiology, pathology, and pharmacology

MA Deli, CS Ábrahám, Y Kataoka, M Niwa - Cellular and molecular …, 2005 - Springer
The specifically regulated restrictive permeability barrier to cells and molecules is the most
important feature of the blood–brain barrier (BBB). The aim of this review was to summarize …

Inflammatory cell trafficking across the blood–brain barrier: chemokine regulation and in vitro models

Y Takeshita, RM Ransohoff - Immunological reviews, 2012 - Wiley Online Library
The blood–brain barrier (BBB) is the brain‐specific capillary barrier that is critical for
preventing toxic substances from entering the central nervous system (CNS). In contrast to …

Blood–brain barrier models and their relevance for a successful development of CNS drug delivery systems: a review

J Bicker, G Alves, A Fortuna, A Falcão - European Journal of Pharmaceutics …, 2014 - Elsevier
During the research and development of new drugs directed at the central nervous system,
there is a considerable attrition rate caused by their hampered access to the brain by the …

In vitro blood–brain barrier models: current and perspective technologies

P Naik, L Cucullo - Journal of pharmaceutical sciences, 2012 - Elsevier
Even in the 21st century, studies aimed at characterizing the pathological paradigms
associated with the development and progression of central nervous system diseases are …

In vitro models of the blood-brain barrier

I Wilhelm, C Fazakas, I Krizbai - Acta neurobiologiae experimentalis, 2011 - ane.pl
The blood-brain barrier (BBB) is an active interface between the circulation and the central
nervous system (CNS) with a dual function: the barrier function restricts the transport from …

In vitro blood–brain barrier models—an overview of established models and new microfluidic approaches

A Wolff, M Antfolk, B Brodin, M Tenje - Journal of pharmaceutical sciences, 2015 - Elsevier
The societal need for new central nervous system (CNS) medicines is substantial, because
of the global increase in life expectancy and the accompanying increase in age-related CNS …