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Involvement of astrocytes in the formation, maintenance, and function of the blood–brain barrier
G Schiera, CM Di Liegro, G Schirò, G Sorbello… - Cells, 2024 - mdpi.com
The blood–brain barrier (BBB) is a fundamental structure that protects the composition of the
brain by determining which ions, metabolites, and nutrients are allowed to enter the brain …
brain by determining which ions, metabolites, and nutrients are allowed to enter the brain …
Looking at the blood–brain barrier: molecular anatomy and possible investigation approaches
FL Cardoso, D Brites, MA Brito - Brain research reviews, 2010 - Elsevier
The blood–brain barrier (BBB) is a dynamic and complex interface between blood and the
central nervous system that strictly controls the exchanges between the blood and brain …
central nervous system that strictly controls the exchanges between the blood and brain …
A 3D neurovascular microfluidic model consisting of neurons, astrocytes and cerebral endothelial cells as a blood–brain barrier
The neurovascular unit is a complex, interdependent system composed of neurons and
neural supporting cells, such as astrocytes, as well as cells that comprise the vascular …
neural supporting cells, such as astrocytes, as well as cells that comprise the vascular …
From adsorption to covalent bonding: Apolipoprotein E functionalization of polymeric nanoparticles for drug delivery across the blood–brain barrier
The blood–brain barrier (BBB) is composed of brain endothelial cells, pericytes, and
astrocytes, which build a tight cellular barrier. Therapeutic (macro) molecules are not able to …
astrocytes, which build a tight cellular barrier. Therapeutic (macro) molecules are not able to …
Permeability studies on in vitro blood–brain barrier models: physiology, pathology, and pharmacology
The specifically regulated restrictive permeability barrier to cells and molecules is the most
important feature of the blood–brain barrier (BBB). The aim of this review was to summarize …
important feature of the blood–brain barrier (BBB). The aim of this review was to summarize …
Inflammatory cell trafficking across the blood–brain barrier: chemokine regulation and in vitro models
Y Takeshita, RM Ransohoff - Immunological reviews, 2012 - Wiley Online Library
The blood–brain barrier (BBB) is the brain‐specific capillary barrier that is critical for
preventing toxic substances from entering the central nervous system (CNS). In contrast to …
preventing toxic substances from entering the central nervous system (CNS). In contrast to …
Blood–brain barrier models and their relevance for a successful development of CNS drug delivery systems: a review
During the research and development of new drugs directed at the central nervous system,
there is a considerable attrition rate caused by their hampered access to the brain by the …
there is a considerable attrition rate caused by their hampered access to the brain by the …
In vitro blood–brain barrier models: current and perspective technologies
P Naik, L Cucullo - Journal of pharmaceutical sciences, 2012 - Elsevier
Even in the 21st century, studies aimed at characterizing the pathological paradigms
associated with the development and progression of central nervous system diseases are …
associated with the development and progression of central nervous system diseases are …
In vitro models of the blood-brain barrier
The blood-brain barrier (BBB) is an active interface between the circulation and the central
nervous system (CNS) with a dual function: the barrier function restricts the transport from …
nervous system (CNS) with a dual function: the barrier function restricts the transport from …
In vitro blood–brain barrier models—an overview of established models and new microfluidic approaches
The societal need for new central nervous system (CNS) medicines is substantial, because
of the global increase in life expectancy and the accompanying increase in age-related CNS …
of the global increase in life expectancy and the accompanying increase in age-related CNS …