The formulation and delivery of biopharmaceutical drugs, such as monoclonal antibodies
and recombinant proteins, poses substantial challenges owing to their large size and …

Tissue engineering is essentially a technique for imitating nature. Natural tissues are made
up of three parts: extracellular matrix (ECM), signaling systems, and cells. Therefore …

Approximately 100,000 individuals in the United States currently await kidney
transplantation, and 400,000 individuals live with end-stage kidney disease requiring …

Discarded human donor organs have been shown to provide decellularized extracellular
matrix (dECM) scaffolds suitable for organ engineering. The quest for appropriate cell …

Tissue engineering has emerged at the intersection of numerous disciplines to meet a
global clinical need for technologies to promote the regeneration of functional living tissues …

Transplantation is the only curative treatment option available for patients suffering from end‐
stage organ failure, improving their quality of life and long‐term survival. However, because …

Biomaterials based on seeding of cells on decellularized scaffolds have gained increasing
interest in the last few years and suggested to serve as an alternative approach to …

The native extracellular matrix (ECM) outlines the architecture of organs and tissues. It
provides a unique niche of composition and form, which serves as a foundational scaffold …

With the advent of whole organ decellularization, extracellular matrix scaffolds suitable for
organ engineering were generated from numerous tissues, including the heart, lung, liver …

The ability to generate patient-specific cells through induced pluripotent stem cell (iPSC)
technology has encouraged development of three-dimensional extracellular matrix (ECM) …