In vivo fluorescence imaging: success in preclinical imaging paves the way for clinical applications

A Refaat, ML Yap, G Pietersz, APG Walsh… - Journal of …, 2022 - Springer
Advances in diagnostic imaging have provided unprecedented opportunities to detect
diseases at early stages and with high reliability. Diagnostic imaging is also crucial to …

[HTML][HTML] Cell membrane camouflaged biomimetic nanoparticles: Focusing on tumor theranostics

L Zhu, Y Zhong, S Wu, M Yan, Y Cao, N Mou, G Wang… - Materials Today Bio, 2022 - Elsevier
Nanoparticles (NPs) modified by cell membranes represent an emerging biomimetic
platform that can mimic the innate biological functions resulting from the various cell …

Aspirin and antiplatelet treatments in cancer

DL Tao, S Tassi Yunga, CD Williams… - Blood, The Journal of …, 2021 - ashpublications.org
Platelets have been hypothesized to promote certain neoplastic malignancies; however,
antiplatelet drugs are still not part of routine pharmacological cancer prevention and …

Platelet cancer cell interplay as a new therapeutic target

K Morris, B Schnoor, AL Papa - … et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
The interaction between circulating tumor cells and platelets is a key factor in cancer
metastasis. These interactions, driven by a variety of receptors, support circulating tumor …

Targeted inhibition of tumor inflammation and tumor-platelet crosstalk by nanoparticle-mediated drug delivery mitigates cancer metastasis

S Li, L Li, X Lin, C Chen, C Luo, Y Huang - ACS nano, 2021 - ACS Publications
Sowing malignant cells (the “seeds” of metastasis) to engraft secondary sites requires a
conducive premetastatic niche (PMN, the “soil” of metastasis). Inflammation and tumor …

Aptamer-based smart targeting and spatial trigger–response drug-delivery systems for anticancer therapy

D Park, SJ Lee, JW Park - Biomedicines, 2024 - mdpi.com
In recent years, the field of drug delivery has witnessed remarkable progress, driven by the
quest for more effective and precise therapeutic interventions. Among the myriad strategies …

Platelets promote CRC by activating the C5a/C5aR1 axis via PSGL-1/JNK/STAT1 signaling in tumor-associated macrophages

X Li, X Chen, S Gong, J Zhao, C Yao, H Zhu… - …, 2023 - pmc.ncbi.nlm.nih.gov
Rationale: Platelets can influence the progression and prognosis of colorectal cancer (CRC)
through multiple mechanisms, including crosstalk with tumor-associated macrophages …

Emerging roles of platelets in cancer biology and their potential as therapeutic targets

L Wang, X Wang, E Guo, X Mao, S Miao - Frontiers in oncology, 2022 - frontiersin.org
The main role of platelets is to control bleeding and repair vascular damage via thrombosis.
They have also been implicated to promote tumor metastasis through platelet-tumor cell …

Platelet-cancer interplay: molecular mechanisms and new therapeutic avenues

A Braun, HJ Anders, T Gudermann… - Frontiers in …, 2021 - frontiersin.org
Although platelets are critically involved in thrombosis and hemostasis, experimental and
clinical evidence indicate that platelets promote tumor progression and metastasis through a …

T cell-mimicking platelet-drug conjugates

Y Yang, Y Wang, Y Yao, S Wang, Y Zhang, G Dotti… - Matter, 2023 - cell.com
Cancer metastasis is the leading cause of cancer-related deaths. The indispensable role of
platelets in tumor metastasis inspires the targeted delivery strategy by using platelet-drug …