[HTML][HTML] Cell death
Cell death supports morphogenesis during development and homeostasis after birth by
removing damaged or obsolete cells. It also curtails the spread of pathogens by eliminating …
removing damaged or obsolete cells. It also curtails the spread of pathogens by eliminating …
RBP–RNA interactions in the control of autoimmunity and autoinflammation
J Liu, X Cao - Cell research, 2023 - nature.com
Autoimmunity and autoinflammation arise from aberrant immunological and inflammatory
responses toward self-components, contributing to various autoimmune diseases and …
responses toward self-components, contributing to various autoimmune diseases and …
TGR5 agonist inhibits intestinal epithelial cell apoptosis via cAMP/PKA/c-FLIP/JNK signaling pathway and ameliorates dextran sulfate sodium-induced ulcerative …
W Yang, F Han, Y Gu, H Qu, J Liu, J Shen… - Acta Pharmacologica …, 2023 - nature.com
Excessive apoptosis of intestinal epithelial cell (IEC) is a crucial cause of disrupted
epithelium homeostasis, leading to the pathogenesis of ulcerative colitis (UC). The …
epithelium homeostasis, leading to the pathogenesis of ulcerative colitis (UC). The …
Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis
Ulcerative colitis (UC) is driven by immune and stromal subsets, culminating in epithelial
injury. Vedolizumab (VDZ) is an anti-integrin antibody that is effective for treating UC. VDZ is …
injury. Vedolizumab (VDZ) is an anti-integrin antibody that is effective for treating UC. VDZ is …
Epithelial TNF controls cell differentiation and CFTR activity to maintain intestinal mucin homeostasis
The gastrointestinal tract relies on the production, maturation, and transit of mucin to protect
against pathogens and to lubricate the epithelial lining. Although the molecular and cellular …
against pathogens and to lubricate the epithelial lining. Although the molecular and cellular …
Regulation mechanisms of disulfidptosis-related genes in ankylosing spondylitis and inflammatory bowel disease
L Li, H Fang, F Li, K **e, P Zhou, H Zhu, X **… - Frontiers in …, 2024 - frontiersin.org
Introduction Disulfidptosis is a recently identified form of cell death that contributes to
maintaining the internal environment balance of an organism. However, the molecular basis …
maintaining the internal environment balance of an organism. However, the molecular basis …
Deubiquitinases in cell death and inflammation
Apoptosis, pyroptosis, and necroptosis are distinct forms of programmed cell death that
eliminate infected, damaged, or obsolete cells. Many proteins that regulate or are a part of …
eliminate infected, damaged, or obsolete cells. Many proteins that regulate or are a part of …
Early subclinical stages of the inflammatory bowel diseases: insights from human and animal studies
The inflammatory bowel diseases (IBD) occur in genetically susceptible individuals that
mount inappropriate immune responses to their microbiota leading to chronic intestinal …
mount inappropriate immune responses to their microbiota leading to chronic intestinal …
Dysregulation of CD4+ and CD8+ resident memory T, myeloid, and stromal cells in steroid-experienced, checkpoint inhibitor colitis
Background Colitis caused by checkpoint inhibitors (CPI) is frequent and is treated with
empiric steroids, but CPI colitis mechanisms in steroid-experienced or refractory disease are …
empiric steroids, but CPI colitis mechanisms in steroid-experienced or refractory disease are …
Spontaneous episodic inflammation in the intestines of mice lacking HNF4A is driven by microbiota and associated with early life microbiota alterations
The inflammatory bowel diseases (IBD) occur in genetically susceptible individuals who
mount inappropriate immune responses to their microbiota leading to chronic intestinal …
mount inappropriate immune responses to their microbiota leading to chronic intestinal …