Develo** novel targeted anticancer therapies is a major goal of current research. The use
of poly (ADP-ribose) polymerase (PARP) inhibitors in patients with homologous …

Complete and accurate DNA replication requires the progression of replication forks through
DNA damage, actively transcribed regions, structured DNA and compact chromatin. Recent …

Cells are exposed to various endogenous and exogenous insults that induce DNA damage,
which, if unrepaired, impairs genome integrity and leads to the development of various …

Cells deficient in the Brca1 and Brca2 genes have reduced capacity to repair DNA double-
strand breaks by homologous recombination and consequently are hypersensitive to DNA …

Poly (ADP-ribose) is synthesized by PARP enzymes during the repair of stochastic DNA
breaks. Surprisingly, however, we show that most if not all endogenous poly (ADP-ribose) is …

Replication protein A (RPA) and RAD51 are DNA-binding proteins that help maintain
genome stability during DNA replication. These proteins regulate nucleases, helicases, DNA …

Besides its role in homologous recombination, the tumor suppressor BRCA2 protects stalled
replication forks from nucleolytic degradation. Defective fork stability contributes to …

Brca2 deficiency causes Mre11-dependent degradation of nascent DNA at stalled forks,
leading to cell lethality. To understand the molecular mechanisms underlying this process …

Germ-line and somatic mutations in genes that promote homology-directed repair (HDR),
especially BRCA1 and BRCA2, are frequently observed in several cancers, in particular …

To ensure the completion of DNA replication and maintenance of genome integrity, DNA
repair factors protect stalled replication forks upon replication stress. Previous studies have …