Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease

T Guo, D Zhang, Y Zeng, TY Huang, H Xu… - Molecular …, 2020 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

Amyloid beta: structure, biology and structure-based therapeutic development

G Chen, T Xu, Y Yan, Y Zhou, Y Jiang… - Acta pharmacologica …, 2017 - nature.com
Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a
transmembrane protein, amyloid precursor protein (APP), by β-and γ-secretases. Aβ …

The Hsp70/Hsp90 chaperone machinery in neurodegenerative diseases

RE Lackie, A Maciejewski, VG Ostapchenko… - Frontiers in …, 2017 - frontiersin.org
The accumulation of misfolded proteins in the human brain is one of the critical features of
many neurodegenerative diseases, including Alzheimer's disease (AD). Assembles of beta …

Implications of peptide assemblies in amyloid diseases

PC Ke, MA Sani, F Ding, A Kakinen, I Javed… - Chemical Society …, 2017 - pubs.rsc.org
Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …

α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B

DG Ferreira, M Temido-Ferreira… - Nature …, 2017 - nature.com
Synucleinopathies, such as Parkinson's disease and dementia with Lewy bodies, are
neurodegenerative disorders that are characterized by the accumulation of α-synuclein …

Metabolism and functions of copper in brain

IF Scheiber, JFB Mercer, R Dringen - Progress in neurobiology, 2014 - Elsevier
Copper is an important trace element that is required for essential enzymes. However, due
to its redox activity, copper can also lead to the generation of toxic reactive oxygen species …

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease

ST Ferreira, MV Lourenco, MM Oliveira… - Frontiers in cellular …, 2015 - frontiersin.org
Alzheimer's disease (AD) is the most common form of dementia in the elderly, and affects
millions of people worldwide. As the number of AD cases continues to increase in both …

An insight into cellular and molecular mechanisms underlying the pathogenesis of neurodegeneration in Alzheimer's disease

Y Ratan, A Rajput, S Maleysm, A Pareek, V Jain… - Biomedicines, 2023 - mdpi.com
Alzheimer's disease (AD) is the most prominent neurodegenerative disorder in the aging
population. It is characterized by cognitive decline, gradual neurodegeneration, and the …

Exploring pathological link between antimicrobial and amyloid peptides

Y Tang, Y Zhang, D Zhang, Y Liu, R Nussinov… - Chemical Society …, 2024 - pubs.rsc.org
Amyloid peptides (AMYs) and antimicrobial peptides (AMPs) are considered as the two
distinct families of peptides, characterized by their unique sequences, structures, biological …

[HTML][HTML] Amyloid-β receptors: the good, the bad, and the prion protein

HH Jarosz-Griffiths, E Noble, JV Rushworth… - Journal of biological …, 2016 - Elsevier
Several different receptor proteins have been identified that bind monomeric, oligomeric, or
fibrillar forms of amyloid-β (Aβ).“Good” receptors internalize Aβ or promote its transcytosis …