Formulating resveratrol and melatonin self-nanoemulsifying drug delivery systems (SNEDDS) for ocular administration using design of experiments

E Zingale, A Bonaccorso, AG D'Amico, R Lombardo… - Pharmaceutics, 2024 - mdpi.com
Recent studies have demonstrated that Sirtuin-1 (SIRT-1)-activating molecules exert a
protective role in degenerative ocular diseases. However, these molecules hardly reach the …

Medical prospect of melatonin in the intervertebral disc degeneration through inhibiting M1-type macrophage polarization via SIRT1/notch signaling pathway

X Dou, Q Luo, L **e, X Zhou, C Song, M Liu, X Liu… - Biomedicines, 2023 - mdpi.com
The study aims to explore the medical prospect of melatonin (MLT) and the underlying
therapeutic mechanism of MLT-mediated macrophage (Mφ) polarization on the function of …

Intravitreal melatonin for the prevention of radiation retinopathy: a step beyond bevacizumab

A Kahvecioglu, E Yigit, N Rustamova… - … Journal of Radiation …, 2025 - Taylor & Francis
Purpose Intravitreal bevacizumab has been utilized to mitigate radiation retinopathy, yet the
potential role of intravitreal melatonin for its prevention remains unexplored. This study aims …

Current state of knowledge on the centrifugal visual system (including the pinealo-to-retinal connection) in mammals and its hypothesized role in circadian rhythms

V Vereczki, K Köves, Á Csáki - Exploration of Neuroscience, 2024 - explorationpub.com
The ubiquity of circadian rhythms in living organisms has generally been accepted by
researchers over the last century. Indeed, morphology and molecular biology of the …