Phage T4 has provided countless contributions to the paradigms of genetics and
biochemistry. Its complete genome sequence of 168,903 bp encodes about 300 gene …

The ribosome is a molecular machine which evolved to translate RNA messages faithfully
and efficiently into a protein product. However, the demands of speed and accuracy conffict …

Dispersed repetitive DNA sequences have been described recently in eubacteria. To assess
the distribution and evolutionary conservation of two distinct prokaryotic repetitive elements …

Legionella pneumophila mutants specifically defective for intracellular replication were
isolated using an intracellular thymineless death enrichment strategy. Mutants belonging to …

This book expands on the previous volumes with new chapters exploring emerging themes
and methodologies in bacterial virus research. The chapters in this book are divided into 4 …

Marine viruses impact global biogeochemical cycles via their influence on host community
structure and function, yet our understanding of viral ecology is constrained by limitations in …

Kinetic and catalytic properties of the DNA (cytosine-5)-methyltransferase HhaI are
described. With poly (dG-dC) as substrate, the reaction proceeds by an equilibrium (or …

Thymidylate synthase (TS; 5, 10-methylenetetrahydrofolate: dUMP C-methyltransferase, EC
2.1. 1.45) is essential for the de novo synthesis of thymidylate, a precursor of DNA. Previous …

Water environments with temperatures up to and above boiling are commonly found in
association with geothermal activity. At temperatures above 60° C, only bacteria are found …

Group I introns form a structural and functional group of introns with widespread but irregular
distribution among very diverse organisms and genetic systems. Evidence is now …