SLC6 neurotransmitter transporters: structure, function, and regulation

AS Kristensen, J Andersen, TN Jørgensen… - Pharmacological …, 2011 - Elsevier
The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …

Mechanisms of dopamine transporter regulation in normal and disease states

RA Vaughan, JD Foster - Trends in pharmacological sciences, 2013 - cell.com
The dopamine (DA) transporter (DAT) controls the spatial and temporal dynamics of DA
neurotransmission by driving reuptake of extracellular transmitter into presynaptic neurons …

Methamphetamine use: a comprehensive review of molecular, preclinical and clinical findings

WJ Panenka, RM Procyshyn, T Lecomte… - Drug and alcohol …, 2013 - Elsevier
Methamphetamine (MA) is a highly addictive psychostimulant drug that principally affects the
monoamine neurotransmitter systems of the brain and results in feelings of alertness …

How addictive drugs disrupt presynaptic dopamine neurotransmission

D Sulzer - Neuron, 2011 - cell.com
The fundamental principle that unites addictive drugs appears to be that each enhances
synaptic dopamine by means that dissociate it from normal behavioral control, so that they …

Amphetamines, new psychoactive drugs and the monoamine transporter cycle

HH Sitte, M Freissmuth - Trends in pharmacological sciences, 2015 - cell.com
In monoaminergic neurons, the vesicular transporters and the plasma membrane
transporters operate in a relay. Amphetamine and its congeners target this relay to elicit their …

Spatial contextual recognition memory updating is modulated by dopamine release in the dorsal hippocampus from the locus coeruleus

DK Gálvez-Márquez… - Proceedings of the …, 2022 - National Acad Sciences
Detecting novelty is critical to consolidate declarative memories, such as spatial contextual
recognition memory. It has been shown that stored memories, when retrieved, are …

SLC6 transporters: structure, function, regulation, disease association and therapeutics

AB Pramod, J Foster, L Carvelli, LK Henry - Molecular aspects of medicine, 2013 - Elsevier
The SLC6 family of secondary active transporters are integral membrane solute carrier
proteins characterized by the Na+-dependent translocation of small amino acid or amino …

Dopamine reuptake and inhibitory mechanisms in human dopamine transporter

Y Li, X Wang, Y Meng, T Hu, J Zhao, R Li, Q Bai… - Nature, 2024 - nature.com
The dopamine transporter has a crucial role in regulation of dopaminergic
neurotransmission by uptake of dopamine into neurons and contributes to the abuse …

Regulation of the dopamine and vesicular monoamine transporters: pharmacological targets and implications for disease

CL German, MG Baladi, LM McFadden… - Pharmacological …, 2015 - Elsevier
Dopamine (DA) plays a well recognized role in a variety of physiologic functions such as
movement, cognition, mood, and reward. Consequently, many human disorders are due, in …

Targeting SLC transporters: small molecules as modulators and therapeutic opportunities

A Schlessinger, N Zatorski, K Hutchinson… - Trends in Biochemical …, 2023 - cell.com
Solute carrier (SLCs) transporters mediate the transport of a broad range of solutes across
biological membranes. Dysregulation of SLCs has been associated with various …