Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is
a widespread tool for structural analysis across academia and the biopharmaceutical …

Chemistry” on HDX MS. 1 That review covered HDX MS applications from January 2012
through June 2014 and described the publications in terms of sector, geography, and topic …

We present a hydrogen/deuterium exchange workflow coupled to tandem mass
spectrometry (HX-MS2) that supports the acquisition of peptide fragment ions alongside their …

Hydrogen–deuterium exchange (HDX) has become a pivotal method for investigating the
structural and dynamic properties of proteins. The versatility and sensitivity of mass …

Hydrogen–deuterium exchange mass spectrometry (HDX/MS) is increasingly used to study
the dynamics of protein conformation. Coupled to native MS, HDX can also characterize the …

Experimental measurement of time-dependent spontaneous exchange of amide protons
with deuterium of the solvent provides information on the structure and dynamical structural …

Antibody drug conjugates (ADCs) have been at the forefront in cancer therapy due to their
target specificity. All the FDA approved ADCs are developed in lyophilized form to minimize …

Mass spectrometry (MS) has made enormous contributions to comprehensive protein
identification and quantification in proteomics. MS is also gaining momentum for structural …

An inherent strength of hydrogen/deuterium exchange coupled to mass spectrometry (HDX-
MS) is its ability to detect the presence of multiple conformational states of a protein, which …

Protein turnover is vital for cellular functioning and is often associated with the
pathophysiology of a variety of diseases. Metabolic labeling with heavy water followed by …