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[HTML][HTML] Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis
J Wang, K Hu, X Cai, B Yang, Q He, J Wang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic interstitial pneumonia
with unknown causes. The incidence rate increases year by year and the prognosis is poor …
with unknown causes. The incidence rate increases year by year and the prognosis is poor …
The role of JAK/STAT pathway in fibrotic diseases: molecular and cellular mechanisms
J Liu, F Wang, F Luo - Biomolecules, 2023 - mdpi.com
There are four members of the JAK family and seven of the STAT family in mammals. The
JAK/STAT molecular pathway could be activated by broad hormones, cytokines, growth …
JAK/STAT molecular pathway could be activated by broad hormones, cytokines, growth …
Stem cell therapy: from idea to clinical practice
M Mousaei Ghasroldasht, J Seok, HS Park… - International journal of …, 2022 - mdpi.com
Regenerative medicine is a new and promising mode of therapy for patients who have
limited or no other options for the treatment of their illness. Due to their pleotropic therapeutic …
limited or no other options for the treatment of their illness. Due to their pleotropic therapeutic …
Potential of nintedanib in treatment of progressive fibrosing interstitial lung diseases
A proportion of patients with fibrosing interstitial lung diseases (ILDs) develop a progressive
phenotype characterised by decline in lung function, worsening quality of life and early …
phenotype characterised by decline in lung function, worsening quality of life and early …
The natural history of progressive fibrosing interstitial lung diseases
A proportion of patients with certain types of interstitial lung disease (ILD), including chronic
hypersensitivity pneumonitis and ILDs associated with autoimmune diseases, develop a …
hypersensitivity pneumonitis and ILDs associated with autoimmune diseases, develop a …
The role of bacteria in the pathogenesis and progression of idiopathic pulmonary fibrosis
Rationale: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease of unknown
cause that leads to respiratory failure and death within 5 years of diagnosis. Overt …
cause that leads to respiratory failure and death within 5 years of diagnosis. Overt …
Pulmonary macrophages: a new therapeutic pathway in fibrosing lung disease?
Pulmonary fibrosis (PF) is a growing clinical problem which can result in breathlessness or
respiratory failure and has an average life expectancy of 3 years from diagnosis …
respiratory failure and has an average life expectancy of 3 years from diagnosis …
Lung microbiome and disease progression in idiopathic pulmonary fibrosis: an analysis of the COMET study
Background The role of the lung microbiome in the pathogenesis of idiopathic pulmonary
fibrosis is unknown. We investigated whether unique microbial signatures were associated …
fibrosis is unknown. We investigated whether unique microbial signatures were associated …
Cellular interactions in the pathogenesis of interstitial lung diseases
Interstitial lung disease (ILD) encompasses a large and diverse group of pathological
conditions that share similar clinical, radiological and pathological manifestations, despite …
conditions that share similar clinical, radiological and pathological manifestations, despite …
Morphine for treatment of cough in idiopathic pulmonary fibrosis (PACIFY COUGH): a prospective, multicentre, randomised, double-blind, placebo-controlled, two-way …
Z Wu, LG Spencer, W Banya, J Westoby… - The Lancet …, 2024 - thelancet.com
Background Idiopathic pulmonary fibrosis is a progressive fibrotic lung disease, with most
patients reporting cough. Currently, there are no proven treatments. We examined the use of …
patients reporting cough. Currently, there are no proven treatments. We examined the use of …