Skeletal muscle requires a highly orchestrated coordination between multiple cell types and
their microenvironment to exert its function and to maintain its homeostasis and regenerative …

Highlights•Numerous pathophysiological features of DMD provide different therapeutic
avenues.•Pharmacolougical therapies target all muscles and are applicable to all DMD …

The thrombospondin (Thbs) family of secreted matricellular proteins are stress-and injury-
induced mediators of cellular attachment dynamics and extracellular matrix protein …

Loss of muscle mass is a feature of chronic illness and aging. Here, we report that skeletal
muscle-specific thrombospondin-1 transgenic mice (Thbs1 Tg) have profound muscle …

Duchenne muscular dystrophy is caused by loss of the dystrophin protein. This pathology is
accompanied by mitochondrial dysfunction contributing to muscle fiber instability. It is known …

Cardiac fibrosis is a common pathologic consequence of stress insult to the heart and is
characterized by abnormal deposition of fibrotic extracellular matrix that compromises …

Duchenne muscular dystrophy (DMD) is a devastating disease featuring skeletal muscle
wasting, respiratory insufficiency, and cardiomyopathy. Historically, respiratory failure has …

Skeletal muscle stem and progenitor cells including those derived from human pluripotent
stem cells (hPSCs) offer an avenue towards personalized therapies and readily fuse to form …

The mitochondrial Ca2+ uniporter (MCU) complex mediates acute mitochondrial Ca2+
influx. In skeletal muscle, MCU links Ca2+ signaling to energy production by directly …

Abstract Thrombospondin-4 (TSP-4) belongs to the thrombospondin protein family that
consists of five highly homologous members. A number of novel functions have been …