The human intestine is colonized by a huge number of microorganisms from the moment of
birth. This set of microorganisms found throughout the human body, is called the microbiota; …

At a time when complex diseases affect globally 280 million people and claim 14 million
lives every year, there is an urgent need to rapidly increase our knowledge into their …

Background Excessive and inappropriate immune responses are the hallmark of several
autoimmune disorders, including the inflammatory bowel diseases (IBD): Crohn's disease …

Gout, the most common inflammatory arthritis, is the result of hyperuricemia and
inflammation induced by monosodium urate (MSU) crystal deposition. However, most …

Objective IL23R plays an important role in the pathogenesis of inflammatory bowel disease
(IBD). The IL23R rs11209026 and rs10889677 polymorphisms have been shown to be …

(Macro)-autophagy is a homeostatic process by which eukaryotic cells dispose of protein
aggregates and damaged organelles. Autophagy is also used to degrade micro-organisms …

Inflammatory Bowel disease (IBD) is a widespread pathological condition with clinical
heterogeneity and with different levels of severity. Although IBD usually occurs in young …

Studies investigating the association between Interleukin-23 receptor (IL-23R) gene
polymorphisms and Crohn's disease (CD) report conflicting results. Thus, a meta-analysis …

Rationale Acute intermittent hypoxia (AIH) shows promise for enhancing motor recovery in
chronic spinal cord injuries and neurodegenerative diseases. However, human trials of AIH …

Background NOD2 and smoking are risk factors for Crohn's disease. We meta-analyzed
NOD2-smoking interactions in Crohn's disease (Phase 1), then explored the effect of age at …