Genetic alterations, including DNA mutations and chromosomal abnormalities, are primary
drivers of tumor formation and cancer progression. These alterations can endow cells with a …

Turnover of cellular proteins is regulated by Ubiquitin Proteasome System (UPS).
Components of this pathway, including the proteasome, ubiquitinating enzymes and …

Over the course of three decades of study, the deubiquitinase Herpesvirus associated
Ubiquitin-Specific Protease/Ubiquitin-Specific Protease 7 (HAUSP/USP7) has gradually …

Deubiquitylating enzymes (DUBs) maintain relative homeostasis of the cellular ubiquitome
by removing the post‐translational modification ubiquitin moiety from substrates. Numerous …

The ubiquitin-proteasome system (UPS) is an essential protein quality controller for
regulating protein homeostasis and autophagy. Ubiquitination is a protein modification …

The cell division cycle 25A (CDC25A) phosphatase is a key regulator of cell cycle
progression that acts on the phosphorylation status of Cyclin–Cyclin-dependent kinase …

Deubiquitylating enzymes (DUBs) are proteases that remove the ubiquitin moiety from
ubiquitylated substrates to antagonize the modification mediated by E3 ubiquitin ligases …

High grade serous ovarian cancer (HGSOC) is a fatal gynecologic malignancy in the US
with limited treatment options. New therapeutic strategies include targeting of the cell cycle …

Conventional screening methods for deubiquitinating enzymes (DUBs) have important
limitations. A loss-of-function study based on the knockout of DUB genes in mammalian cells …

The Maf proteins, including c-Maf, MafA, and MafB, are critical transcription factors in
myelomagenesis. Previous studies demonstrated that Maf proteins are processed by the …