Large-conductance Ca2+ release channels known as ryanodine receptors (RyRs) mediate
the release of Ca2+ from an intracellular membrane compartment, the endo/sarcoplasmic …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a stress‐induced cardiac
channelopathy that has a high mortality in untreated patients. Our understanding has grown …

Recent studies highlighted long noncoding RNAs (lncRNAs) to play an important role in
cardiac development. However, understanding of lncRNAs in cardiac diseases is still …

Cardiac ryanodine receptor (RyR2) gain-of-function mutations cause catecholaminergic
polymorphic ventricular tachycardia, a condition characterized by prominent ventricular …

The high-conductance intracellular calcium (Ca2+) channel RyR2 is essential for the
coupling of excitation and contraction in cardiac muscle. Among various modulators …

Cardiovascular disease is the leading cause of human morbidity and mortality. Dilated
cardiomyopathy (DCM) is the most common form of cardiomyopathy associated with heart …

Background Approximately half of patients with heart failure die suddenly as a result of
ventricular arrhythmias. Although abnormal Ca2+ release from the sarcoplasmic reticulum …

Written for practitioners in the field, this critically acclaimed bestseller provides authoritative
information focused on the investigation of drug-related deaths and practical approaches to …

The endoplasmic reticulum (ER) and sarcoplasmic reticulum (SR) form major intracellular
Ca 2+ stores. Ryanodine receptors (RyRs) are large tetrameric ion channels in the SR and …

Rationale: The conserved long non-coding RNA (lncRNA) myocardial infarction associate
transcript (Miat) was identified for its multiple single-nucleotide polymorphisms that are …