Chikungunya virus is widespread throughout the tropics, where it causes recurrent
outbreaks of chikungunya fever. In recent years, outbreaks have afflicted populations in East …

Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …

Nucleic acid sensing is a critical mechanism by which the immune system monitors for
pathogen invasion. A set of germline‐encoded innate immune receptors detect microbial …

AIM2 is a cytosolic innate immune receptor which recognizes double‐stranded DNA
(dsDNA) released during cellular perturbation and pathogenic assault. AIM2 recognition of …

Recognition of pathogens and altered self must be efficient and highly specific to orchestrate
appropriate responses while limiting excessive inflammation and autoimmune reaction to …

Recognition of DNA by the cell is an important immunological signature that marks the
initiation of an innate immune response. AIM2 is a cytoplasmic sensor that recognizes …

Inflammasomes are a group of protein complex located in cytoplasm and assemble in
response to a wide variety of pathogen‐associated molecule patterns, damage‐associated …

Objective To determine the percentage of patients who would develop chronic inflammatory
rheumatism (CIR) following chikungunya (CHIK) virus disease. Methods We conducted a …

Infection is a dynamic biological process underpinned by a complex interplay between the
pathogen and the host. Microbes from all domains of life, including bacteria, viruses, fungi …

Chikungunya virus (CHIKV) is a re-emerging mosquito-borne virus that displays a large cell
and organ tropism, and causes a broad range of clinical symptoms in humans. It is …