Conspectus Epigenetics is brought to RNA, introducing a new dimension to gene
expression regulation. Among numerous RNA modifications, N 6-methyladenosine (m6A) is …

Conspectus Since the discovery of the first chemically modified RNA nucleotide in 1951,
more than 170 types of chemical modifications have been characterized in RNA so far …

Triple-negative breast cancer (TNBC) is currently the worst prognostic subtype of breast
cancer, and there is no effective treatment other than chemotherapy. Processing of …

Drug resistance in cancer cells significantly diminishes treatment efficacy, leading to
recurrence and metastasis. A critical factor contributing to this resistance is the epigenetic …

The epitranscriptomics field has undergone tremendous growth since the discovery that the
RNA N 6-methyladenosine (m 6 A) modification is reversible and is distributed throughout …

Background Epigenetic modifications of RNA significantly contribute to the regulatory
processes in tumors and have, thus, received considerable attention. The m6A modification …

The majority of cancer patients receive radiotherapy during the course of treatment,
delivered with curative intent for local tumor control or as part of a multimodality regimen …

Abstract Background N6‐methyladenosine (m6A), the most prevalent internal mRNA
modification in eukaryotes, is added by m6A methyltransferases, removed by m6A …

Genomic instability, a hallmark of cancer, is a direct consequence of the inactivation of the
tumor suppressor protein p53. Genetically modified mouse models and human tumor …

RNA modification has emerged as an important epigenetic mechanism that controls
abnormal metabolism and growth in acute myeloid leukaemia (AML). However, the roles of …