Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors

ID Neumann, R Landgraf - Trends in neurosciences, 2012 - cell.com
Oxytocin and vasopressin are regulators of anxiety, stress-co**, and sociality. They are
released within hypothalamic and limbic areas from dendrites, axons, and perikarya …

Neuropathology of stress

PJ Lucassen, J Pruessner, N Sousa, OFX Almeida… - Acta …, 2014 - Springer
Environmental challenges are part of daily life for any individual. In fact, stress appears to be
increasingly present in our modern, and demanding, industrialized society. Virtually every …

[HTML][HTML] The human hypothalamus in mood disorders: The HPA axis in the center

AM Bao, DF Swaab - IBRO reports, 2019 - Elsevier
There are no specific structural neuropathological hallmarks found in the brain of mood
disorders. Instead, there are molecular, functional and structural alterations reported in many …

Depression, anxiety-like behavior and memory impairment are associated with increased oxidative stress and inflammation in a rat model of social stress

G Patki, N Solanki, F Atrooz, F Allam, S Salim - Brain research, 2013 - Elsevier
In the present study, we have examined the behavioral and biochemical effect of induction of
psychological stress using a modified version of the resident-intruder model for social stress …

Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

F Ng, M Berk, O Dean, AI Bush - International Journal of …, 2008 - academic.oup.com
Oxidative stress has been implicated in the pathogenesis of diverse disease states, and may
be a common pathogenic mechanism underlying many major psychiatric disorders, as the …

50 years of hurdles and hope in anxiolytic drug discovery

G Griebel, A Holmes - Nature reviews Drug discovery, 2013 - nature.com
Anxiety disorders are the most prevalent group of psychiatric diseases, and have high
personal and societal costs. The search for novel pharmacological treatments for these …

Both oxytocin and vasopressin are mediators of maternal care and aggression in rodents: from central release to sites of action

OJ Bosch, ID Neumann - Hormones and behavior, 2012 - Elsevier
In the mammalian peripartum period, the activity of both the brain oxytocin and vasopressin
system is elevated as part of the physiological adaptations occurring in the mother. This is …

Neuronal circuits of fear extinction

C Herry, F Ferraguti, N Singewald… - European journal of …, 2010 - Wiley Online Library
Fear extinction is a form of inhibitory learning that allows for the adaptive control of
conditioned fear responses. Although fear extinction is an active learning process that …

The age of anxiety: role of animal models of anxiolytic action in drug discovery

JF Cryan, FF Sweeney - British journal of pharmacology, 2011 - Wiley Online Library
Anxiety disorders are common, serious and a growing health problem worldwide. However,
the causative factors, aetiology and underlying mechanisms of anxiety disorders, as for most …

Vasopressin: behavioral roles of an “original” neuropeptide

HK Caldwell, HJ Lee, AH Macbeth… - Progress in neurobiology, 2008 - Elsevier
Vasopressin (Avp) is mainly synthesized in the magnocellular cells of the hypothalamic
supraoptic (SON) and paraventricular nuclei (PVN) whose axons project to the posterior …