Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Abstract Staining with Congo Red (CR) is a qualitative method used for the identification of
amyloids in vitro and in tissue sections. However, the drawbacks and artefacts obtained …

Background Microglia are the endogenous immune cells of the brain and act as sensors of
pathology to maintain brain homeostasis and eliminate potential threats. In Alzheimer's …

Negative psychological and physiological consequences of neurodegenerative disorders
represent a high social and health cost. Among the neurodegenerative disorders …

Alzheimer's disease (AD) and Type 2 Diabetes Mellitus (T2DM) are two of the most
prevalent diseases in the elderly population worldwide. A growing body of epidemiological …

Soluble oligomers of amyloid β-protein (Aβ) have been defined as aggregates in
supernatants following ultracentrifugation of aqueous extracts from Alzheimer's disease (AD) …

Neurodegenerative diseases are an enormous public health problem, affecting tens of
millions of people worldwide. Nearly all of these diseases are characterized by …

The apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset
Alzheimer disease. Previous studies suggest that reduction of apoE levels through genetic …

Alzheimer's disease (AD) is one of the fastest-growing causes of death and disability in
persons 65 years of age or older, affecting more than 5 million Americans alone. Clinical …

Amyloid Diseases involve the growth of disease specific proteins into amyloid fibrils and
their deposition in protein plaques. Amyloid fibril formation is typically preceded by …