Although it is well established that physical activity increases mitochondrial content in
muscle, the molecular mechanisms underlying this process have only recently been …

Sirtuins or Sir2 family of proteins are a class of NAD+ dependent protein deacetylases which
are evolutionarily conserved from bacteria to humans. Some sirtuins also exhibit mono-ADP …

Chronic caloric restriction (CR) and rapamycin inhibit the mechanistic target of rapamycin
(mTOR) signaling, thereby regulating metabolism and suppressing protein synthesis …

There remains an unmet need to identify novel therapeutic strategies capable of protecting
the myocardium against the detrimental effects of acute ischemia–reperfusion injury (IRI), to …

Aging is characterized by a progressive loss of muscle mass and muscle strength. Declines
in skeletal muscle mitochondria are thought to play a primary role in this process …

This paper addresses how long lifespan can be extended via multiple interventions, such as
dietary supplements [eg, curcumin, resveratrol, sulforaphane, complex phytochemical …

Inhalation of hydrogen (H2) gas has been demonstrated to limit the infarct volume of brain
and liver by reducing ischemia–reperfusion injury in rodents. When translated into clinical …

Dietary restriction can extend life span in most organisms tested to date, suggesting that
mechanisms sensing nutrient and energy availability might regulate longevity. The AMP …

Aging is associated with an overall loss of function at the level of the whole organism that
has origins in cellular deterioration. Most cellular components, including mitochondria …

Not only the prevalence, but also the mortality due to ischaemic cardiovascular disease is
higher in older than in young humans, and the demographic shift towards an ageing …