Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis, comprise a family of disorders characterized by progressive …

As neurons are one of the most highly polarized cells in our body, they require sophisticated
cellular mechanisms to maintain protein homeostasis in their subcellular compartments such …

Liquid-liquid phase separation (LLPS) can drive a multitude of cellular processes by
compartmentalizing biological cells via the formation of dense liquid biomolecular …

RNA methylation at adenosine N6 (m6A) is one of the most common RNA modifications,
impacting RNA stability, transport, and translation. Previous studies uncovered RNA …

Nucleocytoplasmic transport (NCT) decline occurs with aging and neurodegeneration. Here,
we investigated the NCT pathway in models of amyotrophic lateral sclerosis–fused in …

Stress granules (SGs) are cytoplasmic biomolecular condensates containing proteins and
RNAs in response to stress. Ras-GTPase–activating protein binding protein 1 (G3BP1) is a …

Formation of biomolecular condensates through liquid-liquid phase separation (LLPS) has
emerged as a pervasive principle in cell biology, allowing compartmentalization and …

The processes of mRNA export from the nucleus and subsequent mRNA translation in the
cytoplasm are of particular relevance in eukaryotic cells. In highly polarised cells such as …

Biomolecular condensates, some of which are liquid-like during health, can age over time
becoming gel-like pathological systems. One potential source of loss of liquid-like properties …

Synaptic loss is a pathological feature of all neurodegenerative diseases including
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ALS is a disease of …