Selection of the translational initiation site in most eukaryotic mRNAs appears to occur via a
scanning mechanism which predicts that proximity to the 5′ end plays a dominant role in …

Although they were discovered more than 50 years ago, caveolae have remained enigmatic
plasmalemmal organelles. With their characteristic “flasklike” shape and virtually ubiquitous …

We have uncovered the existence of extracellular vesicle (EV)-mediated signaling between
cell types within the adipose tissue (AT) proper. This phenomenon became evident in our …

Caveolin-1 is the principal structural protein of caveolae membranes in fibroblasts and
endothelia. Recently, we have shown that the human CAV-1 gene is localized to a …

Among the membrane compartments of a cell, vesicles known as “caveolae” have long
defied functional characterization. However, since the identification of a family of proteins …

Caveolae are vesicular invaginations of the plasma membrane. The chief structural proteins
of caveolae are the caveolins. Caveolins form a scaffold onto which many classes of …

Caveolin, a 21-24-kDa integral membrane protein, is a principal component of caveolae
membranes. We have suggested that caveolin functions as a scaffolding protein to organize …

G protein-coupled receptors (GPCRs) represent the largest family of cell-surface receptors.
These receptors are natural allosteric proteins because agonist-mediated signaling by …

The caveolin gene family has three members in vertebrates: caveolin-1, caveolin-2, and
caveolin-3. So far, most caveolin-related research has been conducted in mammals, but the …

EGF receptor (EGFR) overexpression correlates with metastasis in a variety of carcinomas,
but the underlying mechanisms are poorly understood. We demonstrated that EGF disrupted …