Copper (I)-catalyzed 1, 3-dipolar cycloaddition between organic azides and terminal
alkynes, commonly known as CuAAC or click chemistry, has been identified as one of the …

Triazoles are important five-membered heterocyclic scaffold due to their extensive biological
activities. This framework can be readily obtained in good to excellent yields on the …

Computational docking can be used to predict bound conformations and free energies of
binding for small-molecule ligands to macromolecular targets. Docking is widely used for the …

Highlights•Triazoles mimic different functional groups, resulting optimal bioisosteres for the
synthesis of new active molecules.•Triazoles present a marked stability under hydrolytic …

Cu (I)-catalyzed azide–alkyne 1, 3-dipolar cycloaddition (CuAAC), popularly known as the
“click reaction”, serves as the most potent and highly dependable tool for facile construction …

The review lays emphasis on the significance of 1, 2, 3-triazoles synthesized via CuAAC
reaction having potential to act as anti-microbial, anti-cancer, anti-viral, anti-inflammatory …

Chemistry, traditionally being the science of synthesis and structural manipulations of
molecules, has gradually undertaken the more challenging task of biology-oriented …

HIV-1 protease inhibitors continue to play an important role in the treatment of HIV/AIDS,
transforming this deadly ailment into a more manageable chronic infection. Over the years …

In the last century, small-molecule natural products were the main inspiration for most drug
discovery programs based either on high-throughput screening (HTS) or rational design …

The Huisgen 1, 3-dipolar cycloaddition reaction of organic azides and alkynes1, 2 has
gained considerable attention in recent years due to the introduction in 2001 of Cu (1) …