Interferon-γ: an overview of signals, mechanisms and functions
Abstract Interferon-γ (IFN-γ) coordinates a diverse array of cellular programs through
transcriptional regulation of immunologically relevant genes. This article reviews the current …
transcriptional regulation of immunologically relevant genes. This article reviews the current …
LPS induction of gene expression in human monocytes
M Guha, N Mackman - Cellular signalling, 2001 - Elsevier
Lipopolysaccharide (LPS [endotoxin]) is the principal component of the outer membrane of
Gram-negative bacteria. Recent studies have elucidated how LPS is recognized by …
Gram-negative bacteria. Recent studies have elucidated how LPS is recognized by …
Metabolic endotoxemia initiates obesity and insulin resistance
Diabetes and obesity are two metabolic diseases characterized by insulin resistance and a
low-grade inflammation. Seeking an inflammatory factor causative of the onset of insulin …
low-grade inflammation. Seeking an inflammatory factor causative of the onset of insulin …
[HTML][HTML] Antimicrobial peptides
Antimicrobial peptides and proteins (AMPs) are a diverse class of naturally occurring
molecules that are produced as a first line of defense by all multicellular organisms. These …
molecules that are produced as a first line of defense by all multicellular organisms. These …
Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction
JC Chow, DW Young, DT Golenbock, WJ Christ… - Journal of Biological …, 1999 - ASBMB
TLR4 is a member of the recently identified Toll-like receptor family of proteins and has been
putatively identified as Lps, the gene necessary for potent responses to lipopolysaccharide …
putatively identified as Lps, the gene necessary for potent responses to lipopolysaccharide …
Multifunctional coatings to simultaneously promote osseointegration and prevent infection of orthopaedic implants
J Raphel, M Holodniy, SB Goodman, SC Heilshorn - Biomaterials, 2016 - Elsevier
The two leading causes of failure for joint arthroplasty prostheses are aseptic loosening and
periprosthetic joint infection. With the number of primary and revision joint replacement …
periprosthetic joint infection. With the number of primary and revision joint replacement …
Invited review: bacterial lipopolysaccharides and innate immunity
C Alexander, ET Rietschel - Journal of endotoxin research, 2001 - journals.sagepub.com
Bacterial lipopolysaccharides (LPS) are the major outer surface membrane components
present in almost all Gram-negative bacteria and act as extremely strong stimulators of …
present in almost all Gram-negative bacteria and act as extremely strong stimulators of …
Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation
Consumption of diets high in fat and calories leads to hyperphagia and obesity, which is
associated with chronic “low-grade” systemic inflammation. Ingestion of a high-fat diet alters …
associated with chronic “low-grade” systemic inflammation. Ingestion of a high-fat diet alters …
Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9)
PE Van den Steen, B Dubois, I Nelissen… - Critical reviews in …, 2002 - Taylor & Francis
The matrix metalloproteinases (MMPs) form an enzyme family of which gelatinase B (MMP-
9) represents the largest and most complex member. We focus here on the biochemical …
9) represents the largest and most complex member. We focus here on the biochemical …
Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2
M Hirschfeld, Y Ma, JH Weis, SN Vogel… - The Journal of …, 2000 - journals.aai.org
Abstract Toll-like receptor (TLR) 2 has recently been associated with cellular responses to
numerous microbial products, including LPS and bacterial lipoproteins. However, many …
numerous microbial products, including LPS and bacterial lipoproteins. However, many …