Methylenetetrahydrofolate (MTHFR), the one-carbon cycle, and cardiovascular risks

S Raghubeer, TE Matsha - Nutrients, 2021 - mdpi.com
The 5-10-methylenetetrahydrofolate reductase (MTHFR) enzyme is vital for cellular
homeostasis due to its key functions in the one-carbon cycle, which include methionine and …

Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases

SC Liew, ED Gupta - European journal of medical genetics, 2015 - Elsevier
Abstract The Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is
associated with various diseases (vascular, cancers, neurology, diabetes, psoriasis, etc) …

Cardiovascular risk factors and venous thromboembolism: a meta-analysis

W Ageno, C Becattini, T Brighton, R Selby… - Circulation, 2008 - ahajournals.org
Background—The concept that venous thromboembolism (VTE) and atherosclerosis are 2
completely distinct entities has recently been challenged because patients with VTE have …

The human obesity gene map: the 2005 update

T Rankinen, A Zuberi, YC Chagnon, SJ Weisnagel… - …, 2006 - Wiley Online Library
This paper presents the 12th update of the human obesity gene map, which incorporates
published results up to the end of October 2005. Evidence from single‐gene mutation …

What can mendelian randomisation tell us about modifiable behavioural and environmental exposures?

GD Smith, S Ebrahim - Bmj, 2005 - bmj.com
Epidemiologists look for modifiable causes of common diseases to improve population
health. However, epidemiological studies may identify spurious “causes.” For example, the …

The pathogenesis of mixed-lineage leukemia

AG Muntean, JL Hess - Annual Review of Pathology …, 2012 - annualreviews.org
Aggressive leukemias arise in both children and adults as a result of rearrangements to the
mixed-lineage leukemia gene (MLL) located on chromosome 11q23. MLL encodes a large …

Risk of venous thromboembolism associated with single and combined effects of Factor V Leiden, Prothrombin 20210A and Methylenetethraydrofolate reductase …

B Simone, V De Stefano, E Leoncini, J Zacho… - European journal of …, 2013 - Springer
Genetic and environmental factors interact in determining the risk of venous
thromboembolism (VTE). The risk associated with the polymorphic variants G1691A of factor …

Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease

J Goveia, P Stapor, P Carmeliet - EMBO molecular medicine, 2014 - embopress.org
The endothelium is the orchestral conductor of blood vessel function. Pathological blood
vessel formation (a process termed pathological angiogenesis) or the inability of endothelial …