Exploiting peptide self-assembly for the development of minimalistic viral mimetics

P Janković, I Šantek, AS Pina, D Kalafatovic - Frontiers in chemistry, 2021 - frontiersin.org
Viruses are natural supramolecular nanostructures that form spontaneously by molecular
self-assembly of complex biomolecules. Peptide self-assembly is a versatile tool that allows …

Bacteria‐Responsive Self‐Assembly of Antimicrobial Peptide Nanonets for Trap‐and‐Kill of Antibiotic‐Resistant Strains

NDT Tram, J Xu, D Mukherjee… - Advanced Functional …, 2023 - Wiley Online Library
Bacterial trap** using nanonets is a ubiquitous immune defense mechanism against
infectious microbes. These nanonets can entrap microbial cells, effectively arresting their …

Data-mining unveils structure–property–activity correlation of viral infectivity enhancing self-assembling peptides

K Kaygisiz, L Rauch-Wirth, A Dutta, X Yu… - Nature …, 2023 - nature.com
Gene therapy via retroviral vectors holds great promise for treating a variety of serious
diseases. It requires the use of additives to boost infectivity. Amyloid-like peptide nanofibers …

Cryo-EM structure and polymorphic maturation of a viral transduction enhancing amyloid fibril

T Heerde, D Schütz, YJ Lin, J Münch, M Schmidt… - Nature …, 2023 - nature.com
Amyloid fibrils have emerged as innovative tools to enhance the transduction efficiency of
retroviral vectors in gene therapy strategies. In this study, we used cryo-electron microscopy …

pH-Dependent Reversible Self-Assembly of β-Lactoglobulin-Derived Reducing Peptides

H Su, H An, S Tan, Y Zhai, Y Fu, T Li - Journal of Agricultural and …, 2024 - ACS Publications
Peptide-based self-assembled nanostructures are emerging vehicles for nutrient delivery
and interface engineering. The present study screened eight β-lactoglobulin (β-Lg) derived …

Inverse design of viral infectivity-enhancing peptide fibrils from continuous protein-vector embeddings

K Kaygisiz, A Dutta, L Rauch-Wirth… - Biomaterials …, 2023 - pubs.rsc.org
Amyloid-like nanofibers from self-assembling peptides can promote viral gene transfer for
therapeutic applications. Traditionally, new sequences are discovered either from screening …

Multiscale Simulations of Self-Assembling Peptides: Surface and Core Hydrophobicity Determine Fibril Stability and Amyloid Aggregation

A Iscen, K Kaygisiz, CV Synatschke, T Weil… - …, 2024 - ACS Publications
Assemblies of peptides and proteins through specific intermolecular interactions set the
basis for macroscopic materials found in nature. Peptides provide easily tunable hydrogen …

Optimized peptide nanofibrils as efficient transduction enhancers for in vitro and ex vivo gene transfer

L Rauch-Wirth, A Renner, K Kaygisiz, T Weil… - Frontiers in …, 2023 - frontiersin.org
Chimeric antigen receptor (CAR)-T cell therapy is a groundbreaking immunotherapy for
cancer. However, the intricate and costly manufacturing process remains a hurdle …

The C-terminal 32-mer fragment of hemoglobin alpha is an amyloidogenic peptide with antimicrobial properties

LR Olari, R Bauer, M Gil Miro, V Vogel… - Cellular and Molecular …, 2023 - Springer
Antimicrobial peptides (AMPs) are major components of the innate immune defense.
Accumulating evidence suggests that the antibacterial activity of many AMPs is dependent …

[HTML][HTML] Transduction enhancing EF-C peptide nanofibrils are endocytosed by macropinocytosis and subsequently degraded

L Rauch-Wirth, D Schütz, R Groß, S Rode, B Glocker… - Biomaterials, 2025 - Elsevier
Retroviral gene transfer is the preferred method for stable, long-term integration of genetic
material into cellular genomes, commonly used to generate chimeric antigen receptor (CAR) …