As a result of the low oral bioavailability of several drugs, there is a renewed interest for
parenteral administration to target their absorption directly into the blood bypassing the long …

The brain is a vital organ that is protected from the general circulation and is distinguished
by the presence of a relatively impermeable blood brain barrier (BBB). Blood brain barrier …

The aim of the study was to design injectable long-acting poly (lactide-co-glycolide)(PLGA)-
based in situ gel implants (ISGI) loaded with the anti-diabetic alogliptin. Providing sustained …

High percentage of diabetic people are diagnosed as type 2 who require daily dosing of an
antidiabetic drug such as Linagliptin (Lina) to manage their blood glucose levels. This study …

Employment of mesoporous silica nanostructures (MSNs) in the drug delivery field has
shown a significant potential for improving the oral delivery of active pharmaceutical …

Zein is composed of nonpolar amino acids and is a water-insoluble protein used as the
matrix-forming agent of localized in situ forming gel (ISG). Therefore, this study prepared …

Localized delivery systems have been typically designed to enhance drug concentration at a
target site and minimize systemic drug toxicity. A rosin/cinnamon oil (CO) in situ forming gel …

The solid dispersion technique is the most effective and widely used approach for increasing
the solubility and release of drugs that have low water solubility. Mirtazapine (MRT) is an …

Risperidone is an antipsychotic drug classified as BCS Class II with low solubility at
physiological pH and orally used in the treatment of schizophrenia. Electrospinning is one of …

Schizophrenic patients often face challenges with adherence to oral regimens. The study
aimed to highlight the potentiality of intranasal ethanol/glycerin-containing lipid …