MIC-1/GDF15 is a stress response cytokine and a distant member of the transforming growth
factor beta (TGFb) superfamily, with no close relatives. It acts via a recently identified …

Growth differentiation factor 15 or macrophage inhibitory cytokine-1 (GDF15/MIC-1) is a
divergent member of the transforming growth factor β superfamily and has a diverse …

Abstract GDF-15 (also MIC-1, NAG-1, PLAB, PTGFB) is a member of the TGF-β superfamily,
which is widely distributed in mammalian tissues and has been shown to play multiple roles …

Abstract Growth differentiation factor 15 (GDF15) is a peptide hormone, and a divergent
member of the transforming growth factor beta (TGFβ) superfamily. In normal physiology …

Pancreatic cancer (PC) is a leading cause of cancer related mortality on a global scale. The
disease itself is associated with a dismal prognosis, partly due to its silent nature resulting in …

Food intake and body weight are controlled by a variety of central and peripheral factors, but
the exact mechanisms behind these processes are still not fully understood. Here we show …

Nonsteroidal anti-inflammatory drug (NSAID) activated gene-1, NAG-1, is a divergent
member of the transforming growth factor-beta (TGF-β) superfamily that plays a complex but …

Abstract Growth differentiation factor-15 (GDF-15) is cytokine involved in the regulation of
multiple systems. Because it has regularly been shown to be increased in cardiovascular …

Background Mutations in the gene encoding thymidine kinase 2 (TK2) result in the
myopathic form of mitochondrial DNA depletion syndrome which is a mitochondrial …

Pharmacological treatment of recombinant growth differentiation factor 15 (GDF15) proteins
reduces body weight in obese rodents and primates. Paradoxically, circulating GDF15 levels …