Mesenchymal stem cell‐based immunomodulation: properties and clinical application

M Wang, Q Yuan, L **e - Stem cells international, 2018 - Wiley Online Library
Mesenchymal stem cells (MSCs) are multipotent stem cells characterized by self‐renewal,
production of clonal cell populations, and multilineage differentiation. They exist in nearly all …

Mesenchymal stem cells and immunomodulation: current status and future prospects

F Gao, SM Chiu, DAL Motan, Z Zhang, L Chen… - Cell death & …, 2016 - nature.com
The unique immunomodulatory properties of mesenchymal stem cells (MSCs) make them
an invaluable cell type for the repair of tissue/organ damage caused by chronic inflammation …

Clinical trials with mesenchymal stem cells: an update

T Squillaro, G Peluso, U Galderisi - Cell transplantation, 2016 - journals.sagepub.com
In the last year, the promising features of mesenchymal stem cells (MSCs), including their
regenerative properties and ability to differentiate into diverse cell lineages, have generated …

Mesenchymal stem cells: a new trend for cell therapy

X Wei, X Yang, Z Han, F Qu, L Shao… - Acta Pharmacologica …, 2013 - nature.com
Mesenchymal stem cells (MSCs), the major stem cells for cell therapy, have been used in
the clinic for approximately 10 years. From animal models to clinical trials, MSCs have …

Human mesenchymal stem cells (MSCs) for treatment towards immune-and inflammation-mediated diseases: review of current clinical trials

LT Wang, CH Ting, ML Yen, KJ Liu, HK Sytwu… - Journal of biomedical …, 2016 - Springer
Human mesenchymal stem cells (MSCs) are multilineage somatic progenitor/stem cells that
have been shown to possess immunomodulatory properties in recent years. Initially met with …

Advances in mesenchymal stem cell therapy for immune and inflammatory diseases: Use of cell-free products and human pluripotent stem cell-derived mesenchymal …

LT Wang, KJ Liu, HK Sytwu, ML Yen… - Stem cells translational …, 2021 - academic.oup.com
Mesenchymal stem cell therapy (MSCT) for immune and inflammatory diseases continues to
be popular based on progressive accumulation of preclinical mechanistic evidence. This …

Shining the light on clinical application of mesenchymal stem cell therapy in autoimmune diseases

SA Jasim, AV Yumashev, WK Abdelbasset… - Stem Cell Research & …, 2022 - Springer
The autoimmune diseases are associated with the host immune system, chronic
inflammation, and immune reaction against self-antigens, which leads to the injury and …

Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study

P Connick, M Kolappan, C Crawley… - The Lancet …, 2012 - thelancet.com
Background More than half of patients with multiple sclerosis have progressive disease
characterised by accumulating disability. The absence of treatments for progressive multiple …

Phenotype, donor age and gender affect function of human bone marrow-derived mesenchymal stromal cells

G Siegel, T Kluba, U Hermanutz-Klein, K Bieback… - BMC medicine, 2013 - Springer
Abstract Background Mesenchymal stromal cells (MSCs) are attractive for cell-based
therapies ranging from regenerative medicine and tissue engineering to immunomodulation …

Mammalian MSC from selected species: Features and applications

C Uder, S Brückner, S Winkler… - Cytometry Part …, 2018 - Wiley Online Library
Mesenchymal stromal/stem cells (MSC) are promising candidates for cellular therapy of
different diseases in humans and in animals. Following the guidelines of the International …