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Systemic lupus erythematosus pathogenesis: interferon and beyond
Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …
Memory B cells
Recent advances in studies of immune memory in mice and humans have reinforced the
concept that memory B cells play a critical role in protection against repeated infections …
concept that memory B cells play a critical role in protection against repeated infections …
Slide-tags enables single-nucleus barcoding for multimodal spatial genomics
Recent technological innovations have enabled the high-throughput quantification of gene
expression and epigenetic regulation within individual cells, transforming our understanding …
expression and epigenetic regulation within individual cells, transforming our understanding …
Efficient evolution of human antibodies from general protein language models
Natural evolution must explore a vast landscape of possible sequences for desirable yet
rare mutations, suggesting that learning from natural evolutionary strategies could guide …
rare mutations, suggesting that learning from natural evolutionary strategies could guide …
Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost
The Omicron variant of SARS-CoV-2 infected many vaccinated and convalescent
individuals,–. Despite the reduced protection from infection, individuals who received three …
individuals,–. Despite the reduced protection from infection, individuals who received three …
Molecular fate-map** of serum antibody responses to repeat immunization
The protective efficacy of serum antibodies results from the interplay of antigen-specific B
cell clones of different affinities and specificities. These cellular dynamics underlie serum …
cell clones of different affinities and specificities. These cellular dynamics underlie serum …
Antibody feedback regulates immune memory after SARS-CoV-2 mRNA vaccination
Feedback inhibition of humoral immunity by antibodies was first documented in 1909.
Subsequent studies showed that, depending on the context, antibodies can enhance or …
Subsequent studies showed that, depending on the context, antibodies can enhance or …
Alternative splicing and related RNA binding proteins in human health and disease
Y Tao, Q Zhang, H Wang, X Yang, H Mu - Signal transduction and …, 2024 - nature.com
Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …
engendering transcript diversity, and modifications in protein structure and functionality …
Compartmentalized ocular lymphatic system mediates eye–brain immunity
The eye, an anatomical extension of the central nervous system (CNS), exhibits many
molecular and cellular parallels to the brain. Emerging research demonstrates that changes …
molecular and cellular parallels to the brain. Emerging research demonstrates that changes …
Antibody-mediated neutralization of SARS-CoV-2
Neutralizing antibodies can block infection, clear pathogens, and are essential to provide
long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies …
long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies …