Simple Summary Chemotherapy of solid tumors has made very slow progress over many
decades. A major problem has been that solid tumors very often contain non-dividing cells …

Cell cycle phase transitions are tightly orchestrated to ensure efficient cell cycle progression
and genome stability. Interrogating these transitions is important for understanding both …

Microglia are the resident tissue macrophages of the central nervous system including the
retina. Under pathophysiological conditions, microglia can signal to Müller cells, the major …

Traditional methods for cell cycle stage classification rely heavily on fluorescence
microscopy to monitor nuclear dynamics. These methods inevitably face the typical …

Background Protein function in eukaryotic cells is often controlled in a cell cycle-dependent
manner. Therefore, the correct assignment of cellular phenotypes to cell cycle phases is a …

In high-throughput applications, accurate and efficient segmentation of cells in fluorescence
microscopy images is of central importance for the quantification of protein expression and …

Historically, the analysis of DNA replication in mammalian tissue culture cells has been
limited to static time points, and the use of nucleoside analogues to pulse-label replicating …

Accurate segmentation of cells in fluorescence microscopy images plays a key role in high-
throughput applications such as quantification of protein expression and the study of cell …

The neocortex expands explosively during embryonic development. The earliest
populations of neural stem cells (NSCs) form a thin pseudostratified epithelium whose …

DNA replication in stem cells is a major challenge for pluripotency preservation and cell fate
decisions. This process involves massive changes in the chromatin architecture and the …