Endoplasmic reticulum stress (ERS) is a cellular stress response characterized by excessive
contraction of the endoplasmic reticulum (ER). It is a pathological hallmark of many …

The ERp57/PDIA3 protein is a pleiotropic member of the PDIs family and, although
predominantly located in the endoplasmic reticulum (ER), has indeed been found in other …

Lung adenocarcinoma (LUAD) is the most common type of lung cancer which accounts for
about 40% of all lung cancers. Early detection, risk stratification and treatment are important …

Thiol-mediated uptake (TMU) is an intriguing enigma in current chemistry and biology. While
the appearance of cell-penetrating activity upon attachment of cascade exchangers (CAXs) …

Covalent amino acid modification significantly expands protein functional capability in
regulating biological processes. Tyrosine residues can undergo phosphorylation, sulfation …

Overexpression of human epidermal growth factor receptor 2 (HER2) in breast and gastric
cancers is associated with a poor prognosis, making it an important therapeutic target. Here …

Fluorescent probes are useful tools for the detection of sulfane sulfurs in biological systems.
In this work, we report the development of SSP4, a widely used probe generated in our …

Background Protein disulfide isomerase A3 (PDIA3) is a member of the protein disulfide
isomerase (PDI) family that participates in protein folding through its protein disulfide …

Vector-borne diseases are a leading cause of death worldwide and pose a substantial
unmet medical need. Pathogens binding to host extracellular proteins (the" exoproteome") …

In this study, a series of 2-and/or 3-substituted juglone derivatives were designed and
synthesized. Among them, 9, 18, 22, 30, and 31 showed stronger inhibition activity against …