Interleukin-6 expression and regulation in astrocytes

NJ Van Wagoner, EN Benveniste - Journal of neuroimmunology, 1999 - Elsevier
The physiological function of interleukin-6 (IL-6) within the central nervous system (CNS) is
complex; IL-6 exerts neurotrophic and neuroprotective effects, and yet can also function as a …

Peptide receptor targeting in cancer: the somatostatin paradigm

F Barbieri, A Bajetto, A Pattarozzi… - … journal of peptides, 2013 - Wiley Online Library
Peptide receptors involved in pathophysiological processes represent promising therapeutic
targets. Neuropeptide somatostatin (SST) is produced by specialized cells in a large number …

Neurochemical and cellular reorganization of the spinal cord in a murine model of bone cancer pain

MJ Schwei, P Honore, SD Rogers… - Journal of …, 1999 - Soc Neuroscience
The cancer-related event that is most disruptive to the cancer patient's quality of life is pain.
To begin to define the mechanisms that give rise to cancer pain, we examined the …

Response variability in attention-deficit/hyperactivity disorder: a neuronal and glial energetics hypothesis

VA Russell, RD Oades, R Tannock, PR Killeen… - Behavioral and Brain …, 2006 - Springer
1. Abstract Background Current concepts of Attention-Deficit/Hyperactivity Disorder (ADHD)
emphasize the role of higher-order cognitive functions and reinforcement processes …

Glial and neuronal cells express functional chemokine receptor CXCR4 and its natural ligand stromal cell‐derived factor 1

A Bajetto, R Bonavia, S Barbero… - Journal of …, 1999 - Wiley Online Library
Chemokines are a family of proteins that chemoattract and activate cells by interacting with
specific receptors on the surface of their targets. The chemokine stromal cell‐derived factor …

Tumour microenvironment and pituitary tumour behaviour

P Marques, M Korbonits - Journal of Endocrinological Investigation, 2023 - Springer
The pituitary tumour microenvironment encompasses a spectrum of non-tumoural cells, such
as immune, stromal or endothelial cells, as well as enzymes and signalling peptides like …

[PDF][PDF] Molecular mechanisms of the antiproliferative activity of somatostatin receptors (SSTRs) in neuroendocrine tumors

T Florio - Front Biosci, 2008 - article.imrpress.com
Introduction 3. Molecular and biochemical characterization of SSTRs 4. Physiological roles
of SSTRs 5. SSTRs and tumor cell proliferation 5.1 Direct antiproliferative effects 5.1. 1 …

The microenvironment of pituitary adenomas: biological, clinical and therapeutical implications

P Marques, AL Silva, D López-Presa, C Faria… - Pituitary, 2022 - Springer
The microenvironment of pituitary adenomas (PAs) includes a range of non-tumoral cells,
such as immune and stromal cells, as well as cell signaling molecules such as cytokines …

The tumour microenvironment of pituitary neuroendocrine tumours

P Marques, AB Grossman, M Korbonits - Frontiers in Neuroendocrinology, 2020 - Elsevier
The tumour microenvironment (TME) includes a variety of non-neoplastic cells and non-
cellular elements such as cytokines, growth factors and enzymes surrounding tumour cells …

Pituitary tumour fibroblast-derived cytokines influence tumour aggressiveness

P Marques, S Barry, E Carlsen… - Endocrine-Related …, 2019 - erc.bioscientifica.com
Tumour-associated fibroblasts (TAFs) are key elements of the tumour microenvironment, but
their role in pituitary neuroendocrine tumours (PitNETs) has been little explored. We …