In the human body, copper is an important trace element and is a cofactor for several
important enzymes involved in energy production, iron metabolism, neuropeptide activation …

How do neurons adapt their endolysosomal system to address the particular challenge of
membrane transport across their elaborate cellular landscape and to maintain proteostasis …

Loss-of-function mutations in the copper (Cu) transporter ATP7A cause Menkes disease.
Menkes is an infantile, fatal, hereditary copper-deficiency disorder that is characterized by …

The unusually high demand for metals in the brain, along with insufficient understanding of
how their dysregulation contributes to neurological diseases, motivates the study of how …

Copper is a biometal essential for normal brain development and function, thus copper
deficiency or excess results in central nervous system disease. Well-characterized disorders …

Copper is vital for numerous cellular functions affecting all tissues and organ systems in the
body. The copper pump, ATP7A is critical for whole-body, cellular, and subcellular copper …

Dysregulation of copper homeostasis in humans is primarily found in two genetic diseases
of copper transport, Menkes and Wilson diseases, which show symptoms of copper …

Living systems are built from a small subset of the atomic elements, including the bulk
macronutrients (C, H, N, O, P, S) and ions (Mg, K, Na, Ca) together with a small but variable …

Copper is controlled by a sophisticated network of transport and storage proteins within
mammalian cells, yet its uptake and efflux occur with rapid kinetics. Present as Cu (I) within …

Altered regulation of copper (Cu) homeostasis may contribute to the development of many
pathologies, such as metabolic, cardiovascular, neurodegenerative and cancerous …