Intestinal epithelium functions as a tissue barrier to prevent interaction between the internal
compartment and the external milieu. Intestinal barrier function also determines epithelial …

Background Epidemiologic evidence and animal studies implicate dietary emulsifiers in
contributing to the increased prevalence of diseases associated with intestinal inflammation …

Inflammatory bowel diseases (IBD) can be broadly divided into Crohn's disease (CD) and
ulcerative colitis (UC) from their clinical phenotypes. Over 150 host susceptibility genes have …

Bavachinin (BVC) is a natural small molecule from the Chinese herb Fructus Psoraleae. It
exhibits numerous pharmacological effects, including anti-cancer, anti-inflammation, anti …

miR-21 is involved in the mechanisms of inflammatory bowel disease (IBD). It negatively
regulates PTEN, which is an upstream regulatory gene of the PI3K/Akt/mTOR signaling …

The Phosphatase and tensin homolog (PTEN) gene is one of the most important tumor
suppressor genes, which acts through its unique protein phosphatase and lipid …

Chronic gut inflammation such as inflammatory bowel disease is believed to be associated
with neurodegenerative diseases in humans. However, the direct evidence for and the …

Background Previous studies suggested miR-21 regulated epithelial–mesenchymal
transition (EMT) and fibrosis in organs. The aim of this study was to explore the role and …

Natural mineral water (NMWs) intake has been traditionally used in the treatment of various
gastrointestinal diseases. We investigated the effect of two French NMWs, one a calcium …

Ulcerative colitis (UC) has multifactorial pathogenesis that acts synergistically, such as
immune system dysregulation and expansion of infectious gut microbiota. Therefore, a …