The mitochondrial genome encodes core subunits of the respiratory chain that drives
oxidative phosphorylation and is, therefore, essential for energy conversion. Advances in …

Abstract tRNAs are key adaptor molecules that decipher the genetic code during translation
of mRNAs in protein synthesis. In contrast to the traditional view of tRNAs as ubiquitously …

The human mitochondrial genome is transcribed into two RNAs, containing mRNAs, rRNAs
and tRNAs, all dedicated to produce essential proteins of the respiratory chain. The precise …

Conspectus RNA modification is a co-or post-transcriptional process by which specific
nucleotides are chemically altered by enzymes after their initial incorporation into the RNA …

RNase P is the endonuclease responsible for the 5′ processing of precursor tRNAs (pre-
tRNAs). Unlike the single-subunit protein-only RNase P (PRORP) found in plants or protists …

Mitochondria are central hubs for cellular metabolism, coordinating a variety of metabolic
reactions crucial for human health. Mitochondria provide most of the cellular energy via their …

Premature ovarian insufficiency (POI) is a common cause of infertility in women,
characterised by amenorrhea and elevated FSH under the age of 40 years. In some cases …

Mitochondrial biogenesis relies on both the nuclear and mitochondrial genomes, and
imbalance in their expression can lead to inborn errors of metabolism, inflammation, and …

The precursor transfer RNAs (pre‐tRNAs) require extensive processing to generate mature
tRNAs possessing proper fold, structural stability, and functionality required to sustain …

Mitochondria are the main site of intracellular synthesis of ATP, which provides energy for
various physiological activities of the cell. Cardiomyocytes have a high density of …