[HTML][HTML] Computer-aided drug repurposing for cancer therapy: approaches and opportunities to challenge anticancer targets
Despite huge efforts made in academic and pharmaceutical worldwide research, current
anticancer therapies achieve effective treatment in a limited number of neoplasia cases only …
anticancer therapies achieve effective treatment in a limited number of neoplasia cases only …
Adapting to stress—chaperome networks in cancer
In this Opinion article, we aim to address how cells adapt to stress and the repercussions
chronic stress has on cellular function. We consider acute and chronic stress-induced …
chronic stress has on cellular function. We consider acute and chronic stress-induced …
R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instability
Transcription poses a threat to genomic stability through the formation of R-loops that can
obstruct progression of replication forks. R-loops are three-stranded nucleic acid structures …
obstruct progression of replication forks. R-loops are three-stranded nucleic acid structures …
The role of mTOR signalling in the regulation of skeletal muscle mass in a rodent model of resistance exercise
Resistance exercise (RE) activates signalling by the mammalian target of rapamycin
(mTOR) and it has been suggested that rapamycin-sensitive mTOR signalling controls RE …
(mTOR) and it has been suggested that rapamycin-sensitive mTOR signalling controls RE …
Identification of aberrant luminal progenitors and mTORC1 as a potential breast cancer prevention target in BRCA2 mutation carriers
R Joyce, R Pascual, L Heitink, BD Capaldo… - Nature Cell …, 2024 - nature.com
Inheritance of a BRCA2 pathogenic variant conveys a substantial life-time risk of breast
cancer. Identification of the cell (s)-of-origin of BRCA2-mutant breast cancer and targetable …
cancer. Identification of the cell (s)-of-origin of BRCA2-mutant breast cancer and targetable …
Different promoter affinities account for specificity in MYC-dependent gene regulation
Enhanced expression of the MYC transcription factor is observed in the majority of tumors.
Two seemingly conflicting models have been proposed for its function: one proposes that …
Two seemingly conflicting models have been proposed for its function: one proposes that …
Unraveling the hidden role of a uORF-encoded peptide as a kinase inhibitor of PKCs
Approximately 40% of human messenger RNAs (mRNAs) contain upstream open reading
frames (uORFs) in their 5′ untranslated regions. Some of these uORF sequences, thought …
frames (uORFs) in their 5′ untranslated regions. Some of these uORF sequences, thought …
RNA-binding proteins in cancer drug discovery
Highlights•RNA-binding proteins (RBPs) are essential for tumorigenesis, immune evasion,
invasion, migration and metastasis, hence promising drug targets in cancer therapy.•Small …
invasion, migration and metastasis, hence promising drug targets in cancer therapy.•Small …
Nascent RNA sequencing analysis provides insights into enhancer-mediated gene regulation
Background Enhancers are distal cis-regulatory elements that control gene expression.
Despite an increasing appreciation of the importance of enhancers in cellular function and …
Despite an increasing appreciation of the importance of enhancers in cellular function and …
[HTML][HTML] Metastasis suppressors: functional pathways
I Khan, PS Steeg - Laboratory Investigation, 2018 - Elsevier
Metastasis is a complex process and a major contributor of death in cancer patients.
Metastasis suppressor genes are identified by their ability to inhibit metastasis at a …
Metastasis suppressor genes are identified by their ability to inhibit metastasis at a …