The blood-brain barrier (BBB) allows the brain to selectively import nutrients and energy
critical to neuronal function while simultaneously excluding neurotoxic substances from the …

Adherens and tight junctions are intercellular junctions crucial for epithelial adhesion and
barrier function in a wide variety of tissues and organisms. In stratifying epithelia, such as the …

Tight junctions contribute to the paracellular barrier, the fence dividing plasma membranes,
and signal transduction, acting as a multifunctional complex in vertebrate epithelial and …

Blood‐brain barrier (BBB) is a dynamic interference that regulates the nutrition and toxic
substance in and out of the central nervous system (CNS), and plays a crucial role in …

Although the C-terminal cytoplasmic tail of the tight junction protein occludin is heavily
phosphorylated, the functional impact of most individual sites is undefined. Here, we show …

Microglia are the resident immune cells of the central nervous system that guarantee
immune surveillance and exert also a modulating role on neuronal synaptic development …

Severe burn injury is often accompanied by intestinal barrier dysfunction, which is closely
associated with post-burn shock, bacterial translocation, systemic inflammatory response …

During morphogenesis, epithelial sheets remodel into complex geometries. How cells
dynamically organise their contact with neighbouring cells in these tightly packed tissues is …

The concept of a blood-brain barrier (BBB) dates back to experiments performed by Paul
Ehrlich. Using “intravital tracers” which change their color depending on their oxidative state …

Despite advances in neurology, drug delivery to the central nervous system is considered a
challenge due to the presence of the blood brain barrier (BBB). In this study, the role of …