[HTML][HTML] Past, present and future of therapeutic strategies against amyloid-β peptides in Alzheimer's disease: A systematic review
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing,
affecting around 46 million people worldwide but few treatments are currently available. The …
affecting around 46 million people worldwide but few treatments are currently available. The …
Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease
Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …
Sex specific molecular networks and key drivers of Alzheimer's disease
Background Alzheimer's disease (AD) is a progressive and age-associated
neurodegenerative disorder that affects women disproportionally. However, the underlying …
neurodegenerative disorder that affects women disproportionally. However, the underlying …
Is hormone replacement therapy a risk factor or a therapeutic option for Alzheimer's disease?
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that accounts for
more than half of all dementia cases in the elderly. Interestingly, the clinical manifestations of …
more than half of all dementia cases in the elderly. Interestingly, the clinical manifestations of …
Sex and gender differences in neurodegenerative diseases: challenges for therapeutic opportunities
The term “neurodegenerative diseases”(NDs) identifies a group of heterogeneous diseases
characterized by progressive loss of selectively vulnerable populations of neurons, which …
characterized by progressive loss of selectively vulnerable populations of neurons, which …
Chromosome X-wide association study in case control studies of pathologically confirmed Alzheimer's disease in a European population
E Simmonds, G Leonenko, U Yaman, E Bellou… - Translational …, 2024 - nature.com
Although there are several genome-wide association studies available which highlight
genetic variants associated with Alzheimer's disease (AD), often the X chromosome is …
genetic variants associated with Alzheimer's disease (AD), often the X chromosome is …
Epigenetic mechanisms regulate sex-specific bias in disease manifestations
Sex presents a vital determinant of a person's physiology, anatomy, and development.
Recent clinical studies indicate that sex is also involved in the differential manifestation of …
Recent clinical studies indicate that sex is also involved in the differential manifestation of …
Chromosome instability, aging and brain diseases
Chromosome instability (CIN) has been repeatedly associated with aging and progeroid
phenotypes. Moreover, brain-specific CIN seems to be an important element of pathogenic …
phenotypes. Moreover, brain-specific CIN seems to be an important element of pathogenic …
Complement-mediated synapse loss in Alzheimer's disease: mechanisms and involvement of risk factors
L Wen, D Bi, Y Shen - Trends in Neurosciences, 2024 - cell.com
The complement system is increasingly recognized as a key player in the synapse loss and
cognitive impairments observed in Alzheimer's disease (AD). In particular, the process of …
cognitive impairments observed in Alzheimer's disease (AD). In particular, the process of …
[HTML][HTML] Chronic nSMase inhibition suppresses neuronal exosome spreading and sex-specifically attenuates amyloid pathology in APP knock-in Alzheimer's disease …
Female biased pathology and cognitive decline in Alzheimer's disease (AD) have been
consistently observed with unclear underlying mechanisms. Although brain sphingolipid …
consistently observed with unclear underlying mechanisms. Although brain sphingolipid …