Lipid-based carriers represent the most widely used alternative to viral vectors for gene
expression and gene silencing purposes. This class of non-viral vectors is particularly …

Conspectus The cyclic GMP-AMP synthase-stimulator interferon gene (cGAS-STING)
pathway is an emerging therapeutic target for the prophylaxis and therapy of a variety of …

Current nucleoside-modified RNA lipid nanoparticle (modmRNA-LNP) technology has
successfully paved the way for the highest clinical efficacy data from next-generation …

Therapeutic nucleic acids hold great promise for the treatment of disease but require vectors
for safe and effective delivery. Synthetic nanoparticle vectors composed of poly (β‐amino …

Hypoxia is an important feature, which can upregulate the hypoxia‐inducible factor‐1α (HIF‐
1α) expression and promote the activation of hepatic stellate cells (HSCs), leading to liver …

Lipid nanoparticles have great potential for delivering nucleic-acid-based therapeutics, but
low efficiency limits their broad clinical translation. Differences in transfection capacity …

Inspired by the remarkable ability of natural protein switches to sense and respond to a wide
range of environmental queues, here we report a strategy to engineer synthetic protein …

Cancer is one of the leading causes of death worldwide, and conventional cancer therapies
such as surgery, chemotherapy, and radiotherapy do not address the underlying molecular …

Oligonucleotide therapeutics have the potential to become a third pillar of drug development
after small molecules and protein therapeutics. However, the three approved …

The intracellular delivery of nucleic acid molecules is a complex process involving several
distinct steps; among these the endosomal escape appeared to be of particular importance …