Epilepsy is a chronic neurological condition characterized by recurrent seizures that affects
millions of people worldwide. Comprehension of the complex mechanisms underlying …

A great number of clinical observations show a relationship between epilepsy and
depression. Idiopathic generalized epilepsy, including absence epilepsy, has a genetic …

First characterized in 1982, the genetic absence epilepsy rat from Strasbourg (GAERS) has
emerged as an animal model highly reminiscent of a specific form of idiopathic generalized …

Low voltage-activated (LVA) T-type calcium channels are well regarded as a key
mechanism underlying the generation of neuronal burst-firing. Their low threshold for …

Network mechanisms relevant for the generation, maintenance and termination of spike-
wave discharges (SWD), the neurophysiological hallmark of absence epilepsy, are still …

Epilepsy, a heterogeneous group of brain-related diseases, has continued to significantly
burden society and families. Epilepsy comorbid with neurodevelopmental disorders (NDDs) …

Generalised epileptic seizures are frequently accompanied by sudden, reversible transitions
from low amplitude, irregular background activity to high amplitude, regular spike–wave …

Objective Genetic alterations have been identified in the CACNA 1H gene, encoding the
CaV3. 2 T‐type calcium channel in patients with absence epilepsy, yet the precise …

This review discusses the long-term effects of early-life environment on epileptogenesis,
epilepsy, and neuropsychiatric comorbidities with an emphasis on the absence epilepsy …

A mesoscale network model is proposed for the development of spike and wave discharges
(SWDs) in the cortico-thalamo-cortical (CTC) circuit. It is based on experimental findings in …