Transcription factors (TFs) regulate gene expression by binding to DNA sequences and
modulating transcriptional activity through their effector domains. Despite the central role of …

Alveolar bone is the thickened ridge of jaw bone that supports teeth. It is subject to constant
occlusal force and pathogens invasion, and is therefore under active bone remodeling and …

CX3CL1 is one of the 50 up-to-date identified and characterized chemokines. While other
chemokines are produced as small, secreted proteins, CX3CL1 (fractalkine) is synthetized …

Cooperativity and antagonism between transcription factors (TFs) can drastically modify their
binding to regulatory DNA elements. While map** these relationships between TFs is …

Technological advancement, data democratisation, and decreasing costs have led to a
revolution in molecular biology in which the entire set of DNA, RNA, proteins, and various …

HIV-1 establishes a persistent proviral reservoir by integrating into the genome of infected
host cells. Current antiretroviral treatments do not target this persistent population of …

Simple Summary The most successful strategies for solid cancer immunotherapy have
centered on targeting the co-stimulatory and co-inhibitory T cell molecules that regulate T …

Following gene expansion during evolution, today's phylogenetic tree of the NR2F family of
nuclear orphan receptors in mammals is represented by three different isoforms: NR2F1 …

Immune function is highly controlled at the transcriptional level by the binding of transcription
factors (TFs) to promoter and enhancer elements. Several TF families play major roles in …

NR2F6 has emerged as a key player in immune regulation, especially in cancer immunity. It
has indeed been reported that NR2F6 could suppress the anti-tumor immune response, and …