3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor‐on‐a‐Chip
Decades of efforts in engineering in vitro cancer models have advanced drug discovery and
the insight into cancer biology. However, the establishment of preclinical models that enable …
the insight into cancer biology. However, the establishment of preclinical models that enable …
Advances in microfluidic technologies in organoid research
Organoids have emerged as major technological breakthroughs and novel organ models
that have revolutionized biomedical research by recapitulating the key structural and …
that have revolutionized biomedical research by recapitulating the key structural and …
Cardiac ischemia on-a-chip to investigate cellular and molecular response of myocardial tissue under hypoxia
J Veldhuizen, R Chavan, B Moghadas, JG Park… - Biomaterials, 2022 - Elsevier
Tissue engineering has enabled the development of advanced and physiologically relevant
models of cardiovascular diseases, with advantages over conventional 2D in vitro assays …
models of cardiovascular diseases, with advantages over conventional 2D in vitro assays …
A three-dimensional (3D) organotypic microfluidic model for glioma stem cells–Vascular interactions
Glioblastoma (GBM) is one of the deadliest forms of cancer. Despite many treatment options,
prognosis of GBM remains dismal with a 5-year survival rate of 4.7%. Even then, tumors …
prognosis of GBM remains dismal with a 5-year survival rate of 4.7%. Even then, tumors …
Engineered 3D ex vivo models to recapitulate the complex stromal and immune interactions within the tumor microenvironment
Cancer thrives in a complex environment where interactions between cellular and acellular
components, surrounding the tumor, play a crucial role in disease development and …
components, surrounding the tumor, play a crucial role in disease development and …
A human organotypic microfluidic tumor model permits investigation of the interplay between patient-derived fibroblasts and breast cancer cells
Tumor–stroma interactions significantly influence cancer cell metastasis and disease
progression. These interactions are partly comprised of the cross-talk between tumor and …
progression. These interactions are partly comprised of the cross-talk between tumor and …
Microfluidic tumor–vascular model to study breast cancer cell invasion and intravasation
Cancer is a major leading cause of disease‐related death in the world. The severe impact of
cancer can be attributed to poor understanding of the mechanisms involved in earliest steps …
cancer can be attributed to poor understanding of the mechanisms involved in earliest steps …
Engineering anisotropic human stem cell-derived three-dimensional cardiac tissue on-a-chip
J Veldhuizen, J Cutts, DA Brafman, RQ Migrino… - Biomaterials, 2020 - Elsevier
Despite significant efforts in the study of cardiovascular diseases (CVDs), they persist as the
leading cause of mortality worldwide. Considerable research into human pluripotent stem …
leading cause of mortality worldwide. Considerable research into human pluripotent stem …
[HTML][HTML] On-chip recapitulation of the tumor microenvironment: A decade of progress
One of the hurdles to the development of new anticancer therapies is the lack of in vitro
models which faithfully reproduce the in vivo tumor microenvironment (TME). Understanding …
models which faithfully reproduce the in vivo tumor microenvironment (TME). Understanding …
SAHA and EGCG promote apoptosis in triple-negative breast cancer cells, possibly through the modulation of cIAP2
KL Steed, HR Jordan, TO Tollefsbol - Anticancer research, 2020 - ar.iiarjournals.org
Background/Aim: Inhibition of apoptosis is one of the hallmarks of cancer, and anti-apoptotic
genes are often targets of genetic and epigenetic alterations. Cellular inhibitor of apoptosis 2 …
genes are often targets of genetic and epigenetic alterations. Cellular inhibitor of apoptosis 2 …