Approximately 20% of patients diagnosed with a phaeochromocytoma or paraganglioma
carry a germline mutation in one of the succinate dehydrogenase (SDHx) genes (SDHA …

A molecular biology–based taxonomy has been proposed for pheochromocytoma and
paraganglioma (PPGL). Data from the Cancer Genome Atlas revealed clinically relevant …

Objective: The aim was to formulate clinical practice guidelines for pheochromocytoma and
paraganglioma (PPGL). Participants: The Task Force included a chair selected by the …

Metastasis is the most frequent cause of death in cancer patients. Epithelial-to-mesenchymal
transition (EMT) is the process in which cells lose epithelial integrity and become motile, a …

Paragangliomas and phaeochromocytomas are neuroendocrine tumours whose
pathogenesis and progression are very strongly influenced by genetics. A germline mutation …

Paragangliomas are neuroendocrine tumors frequently associated with mutations in RET,
NF1, VHL, and succinate dehydrogenase (SDHx) genes. Methylome analysis of a large …

The neuroendocrine tumours pheochromocytomas and paragangliomas carry the highest
degree of heritability in human neoplasms, enabling genetic alterations to be traced to …

Tumors driven by deficiency of the VHL gene product, which is involved in degradation of
the hypoxia-inducible factor subunit 2 alpha (HIF2α), are natural candidates for targeted …

Paragangliomas and pheochromocytomas (PPGL) are rare neuroendocrine tumours
characterized by a strong genetic determinism. Over the past 20 years, evolution of PPGL …

Phaeochromocytomas are rare neuroendocrine tumours with a highly variable clinical
presentation but most commonly presenting with episodes of headaches, sweating …